Rea Ravin

TL;DR: This work generated cells expressing insulin and other pancreatic endocrine hormones from mouse ES cells that self-assemble to form three-dimensional clusters similar in topology to normal pancreatic islets where pancreatic cell types are in close association with neurons.

TL;DR: Notch receptor activation induces the expression of the specific target genes hairy and enhancer of split 3 and Sonic hedgehog through rapid activation of cytoplasmic signals, including the serine/threonine kinase Akt, the transcription factor STAT3 and mammalian target of rapamycin, and thereby promotes the survival of neural stem cells.

TL;DR: Using single-cell-based observation, this work provides definitive evidence that GSCs are capable of different modes of cell division and that the generation of cellular diversity occurs mainly through symmetric cell division, not through asymmetric cell divisions.

TL;DR: It is demonstrated that CNTF both directs astrogliogenesis from tripotent cells, bypassing two of the three normal bipotent intermediates, and later promotes the expansion of specified astrocytic progenitors.

TL;DR: The phenotypic and genomic alterations observed in spontaneously transformed murine epithelial cells recapitulated the aberration pattern observed during human carcinogenesis, and are proposed to be useful tools to dissect the sequential steps of genome mutations during malignant transformation, and also to identify cancer‐specific genes, signaling pathways, and the role of chromosomal instability in this process.