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Ivan Zanoni
Researcher at Boston Children's Hospital
Publications - 112
Citations - 6957
Ivan Zanoni is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 36, co-authored 106 publications receiving 5323 citations. Previous affiliations of Ivan Zanoni include Harvard University & University of Milan.
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Induction of peripheral T cell tolerance by antigen-presenting B cells. I. Relevance of antigen presentation persistence.
TL;DR: Investigation of the peripheral conditions of Ag presentation required to induce T cell tolerance when the predominant APCs are B cells shows that transient Ag presentation, in absence of inflammation and in a self-context, induces CD4+ T cell activation and memory formation.
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Targeting innate immunity by blocking CD14: Novel approach to control inflammation and organ dysfunction in COVID-19 illness.
TL;DR: It is proposed that the viral infection initially triggers a profound activation of innate immunity in the lungs that generates a self-perpetuating cytokine storm affecting the entire body that leads to critical illness and life-threatening acute respiratory failure.
Journal ArticleDOI
The dendritic cell life cycle.
Francesca Granucci,Ivan Zanoni +1 more
TL;DR: The possible role of CD14 in initiating this pathway and the way in which the c2 and c3 isoforms of NFAT exert their pro-apoptotic effects are considered.
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Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.
Ning-Ning Liu,Ning-Ning Liu,Priya Uppuluri,Achille Broggi,Angelique N. Besold,Kicki Ryman,Hiroto Kambara,Norma V. Solis,Viola Lorenz,Wanjun Qi,Maikel Acosta-Zaldívar,S. Noushin Emami,Bin Bao,Dingding An,Francisco A. Bonilla,Martha Sola-Visner,Scott G. Filler,Hongbo R. Luo,Ylva Engström,Per O. Ljungdahl,Valeria C. Culotta,Ivan Zanoni,Ivan Zanoni,Jose L. Lopez-Ribot,Julia Koehler +24 more
TL;DR: It is found that loss of Candida albicans Pho84 attenuated virulence in Drosophila and murine oropharyngeal and disseminated models of invasive infection, and conferred hypersensitivity to neutrophil killing, and its role in TORC1 activation to impact oxidative stress management was found.
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Luminescent rhenium and ruthenium complexes of an amphoteric poly(amidoamine) functionalized with 1,10-phenanthroline.
Daniela Maggioni,Fabio Fenili,Laura D'Alfonso,Daniela Donghi,Monica Panigati,Ivan Zanoni,Roberta Marzi,Amedea Manfredi,Paolo Ferruti,Giuseppe D'Alfonso,Elisabetta Ranucci +10 more
TL;DR: A preliminary investigation of internalization in HEK-293 cells showed that Ru-PhenISA enters cells via an endocytic pathway and, subsequently, homogeneously diffuse within the cytoplasm across the vesicle membranes.