T
Thomas R. Martin
Researcher at University of Washington
Publications - 304
Citations - 27987
Thomas R. Martin is an academic researcher from University of Washington. The author has contributed to research in topics: Lung injury & Bronchoalveolar lavage. The author has an hindex of 88, co-authored 257 publications receiving 26085 citations. Previous affiliations of Thomas R. Martin include United States Department of Veterans Affairs & Veterans Health Administration.
Papers
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Journal ArticleDOI
Into the Eye of the Cytokine Storm
Jennifer R. Tisoncik,Marcus J. Korth,Cameron P. Simmons,Jeremy Farrar,Thomas R. Martin,Michael G. Katze +5 more
TL;DR: How high-throughput genomic methods are revealing the importance of the kinetics of cytokine gene expression and the remarkable degree of redundancy and overlap in cytokine signaling is highlighted.
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Animal models of acute lung injury.
TL;DR: The goal of this review is to summarize the strengths and weaknesses of existing models of lung injury and help guide investigators in the design and interpretation of animal studies of acute lung injury.
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An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation : I. The roles of minor H antigens and endotoxin
Kenneth R. Cooke,Lester Kobzik,Thomas R. Martin,Joanne P. Brewer,John Delmonte,James M. Crawford,James L.M. Ferrara +6 more
TL;DR: This murine BMT system is a potentially useful model of clinical IPS; minor H differences between donor and recipient can be important stimuli in the pathogenesis of IPS; and endotoxin in BAL fluid is associated with lung injury, and excess endotoxin can cause the development of alveolar hemorrhage in this model.
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Injurious Mechanical Ventilation and End-Organ Epithelial Cell Apoptosis and Organ Dysfunction in an Experimental Model of Acute Respiratory Distress Syndrome
Yumiko Imai,Jean Parodo,Osamu Kajikawa,Marc de Perrot,Stefan Fischer,Vern Edwards,Ernest Cutz,Mingyao Liu,Shaf Keshavjee,Thomas R. Martin,John C. Marshall,V. Marco Ranieri,Arthur S. Slutsky +12 more
TL;DR: In this paper, the authors examined the hypothesis that an injurious ventilatory strategy may lead to end-organ epithelial cell apoptosis and organ dysfunction, and showed that a lung protection strategy led to increased rates of epithelialcell apoptosis in the kidney.
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Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.
Jonathan M. Spergel,Emiko Mizoguchi,Joanne P. Brewer,Thomas R. Martin,Atul K. Bhan,Raif S. Geha +5 more
TL;DR: A murine model of epicutaneous (EC) sensitization to the protein allergen, chicken egg albumin, ovalbumin, OVA results in a rise in total and OVA-specific serum IgE and leads to the development of a dermatitis characterized by infiltration of CD3(+) T cells, eosinophils, and neutrophils.