J
J Breton-Gorius
Researcher at French Institute of Health and Medical Research
Publications - 70
Citations - 3563
J Breton-Gorius is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Megakaryocyte & Population. The author has an hindex of 35, co-authored 70 publications receiving 3523 citations. Previous affiliations of J Breton-Gorius include John Radcliffe Hospital.
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Journal ArticleDOI
Expression of platelet membrane glycoproteins and alpha-granule proteins by a human erythroleukemia cell line (HEL).
Antonio Tabilio,Jean-Philippe Rosa,Ugo Testa,N Kieffer,Alan T. Nurden,M.C. del Cañizo,J Breton-Gorius,William Vainchenker +7 more
TL;DR: It is demonstrated that HEL, a human erythroleukemic cell line, has numerous megakaryocytic markers which were markedly enhanced following the addition of the inducers dimethyl sulfoxide or 12‐O‐tetradecanoylphorbol‐13‐acetate to the culture medium.
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Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivo cells from normal and leukemic patients
William Vainchenker,William Vainchenker,J F Deschamps,J F Deschamps,J M Bastin,J M Bastin,Josette Guichard,Josette Guichard,Monique Titeux,Monique Titeux,J Breton-Gorius,J Breton-Gorius,Andrew J. McMichael,Andrew J. McMichael +13 more
TL;DR: In this article, two monoclonal anti-human platelet antibodies have been used in an immunofluorescent assay to study megakaryocyte maturation, and the two antibodies were specific for platelets and Megakaryocytes.
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Megakaryoblastic acute leukemia: identification by the ultrastructural demonstration of platelet peroxidase
TL;DR: In this paper, the platelet peroxidase (PPO) was used as a marker of normal small megakaryoblast (MKB) leukemia, and the presence of PPO alone has permitted them to classify this case as a pure small MKB leukemia.
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Immunological study of in vitro maturation of human megakaryocytes
G. Vinci,Antonio Tabilio,J F Deschamps,D. Haeke,A. Henri,Josette Guichard,P. A. T. Tetteroo,Peter M. Lansdorp,T. Hercend,William Vainchenker,J Breton-Gorius +10 more
TL;DR: Cytoplasmic markers demonstrated that these small megakaryocyte precursors were themselves heterogenous by morphological criteria, and double‐fluorescent labelling demonstrated that the different platelet markers were coexpressed in a large majority of cells.
Journal Article
Myeloid and Megakaryocytic Properties of K-562 Cell Lines
Antonio Tabilio,Pier Giuseppe Pelicci,G. Vinci,P. Mannoni,Curt I. Civin,William Vainchenker,Ugo Testa,M. Lipinski,Henri Rochant,J Breton-Gorius +9 more
TL;DR: K-562 cells showed a membrane phenotype similar to that of a normal or leukemic promyelocyte but lacking myeloperoxidase, and this results could be explained by the expression of multilineage markers in a single cell.