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Peter M. Lansdorp

Researcher at University of British Columbia

Publications -  344
Citations -  46785

Peter M. Lansdorp is an academic researcher from University of British Columbia. The author has contributed to research in topics: Telomere & Haematopoiesis. The author has an hindex of 105, co-authored 330 publications receiving 43982 citations. Previous affiliations of Peter M. Lansdorp include University of Amsterdam & Francis Crick Institute.

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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

TL;DR: Results indicate that telomerase is essential for telomere length maintenance but is not required for establishment of cell lines, oncogenic transformation, or tumor formation in mice.
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Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells

TL;DR: It is demonstrated that monocyte-derived hepatocyte-stimulating factor and IFN-beta 2 share immunological and functional identity and that IFN -beta 2, also known as B-cell stimulatory factor and hybridoma plasmacytoma growth factor, has the hepatocyte as a major physiologic target and thereby is essential in controlling the hepatic acute phase response.
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Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis

TL;DR: In this paper, the authors found that mutations in the genes encoding telomerase components can appear as familial idiopathic pulmonary fibrosis, which is a rare hereditary disorder associated with premature death from aplastic anemia and lung fibrosis.
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Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age

TL;DR: It is shown that candidate human stem cells with a CD34+CD38lo phenotype that were purified from adult bone marrow have shorter telomeres than cells from fetal liver or umbilical cord blood and that cells produced in cytokine-supplemented cultures of purified precursor cells show a proliferation-associated loss of telomeric DNA.