J
J. Cristobal Lopez
Researcher at Spanish National Research Council
Publications - 168
Citations - 2439
J. Cristobal Lopez is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Radical cyclization & Glycosyl. The author has an hindex of 24, co-authored 168 publications receiving 2263 citations. Previous affiliations of J. Cristobal Lopez include North Carolina State University & Durham University.
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A novel entry to 5a-carba-hexopyranoses from carbohydrates based on a 6-exo-dig radical cyclization: synthesis of 5a-carba-β-D-mannopyranose pentaacetate
TL;DR: Carbohydrate-derived 2,3:4,6-diacetonides undergo a 6-exo-dig radical cyclization, from a radical located at C-5, to yield highly functionalized cyclohexanes that are correlated with carba-sugars as mentioned in this paper.
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6-endo Versus 5-exo radical cyclization: streamlined syntheses of carbahexopyranoses and derivatives by 6-endo-trig radical cyclization
TL;DR: In this paper, three factors that can direct 6-endo radical cyclization over 5-exo ring closure were considered in the context of the preparation of carbapyranoses from carbohydrate derivatives.
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Unexpected stereocontrolled access to 1α,1'β-disaccharides from methyl 1,2-ortho esters.
TL;DR: Mannopyranose-derived methyl 1, 2-orthoacetates and 1,2-orthobenzoates undergo stereoselective formation of 1α,1'β-disaccharides, rather than the expected acid-catalyzed reaction leading to methyl glycosides by way of a rearrangement-glycosylation process of the liberated methanol.
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Expeditious entry to C-alkyl and C-aryl pyranoid glycals: reaction of anomeric glycosyl chlorides with organolithiums
TL;DR: Treatment of ether-substituted glycopyranosyl chlorides with organolithium reagents gives the corresponding C-glycals in acceptable to good yields as discussed by the authors.
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Formation and reactivity of new Nicholas–Ferrier pyranosidic cations: novel access to oxepanes via a 1,6-hydride shift/cyclization sequence
TL;DR: Pyranosidic allylic cations that share dicobalt hexacarbonyl propargyl (Nicholas) stabilization at C-1 display a remarkable reactivity leading to either substituted oxepanes or 3-C-branched pyranosides, depending on the substituent at O-6.