G
George K. Dresser
Researcher at University of Western Ontario
Publications - 77
Citations - 9122
George K. Dresser is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Grapefruit juice & Blood pressure. The author has an hindex of 36, co-authored 74 publications receiving 8167 citations. Previous affiliations of George K. Dresser include Vanderbilt University & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Identification of functionally variant MDR1 alleles among European Americans and African Americans
Richard B. Kim,Richard B. Kim,Brenda F. Leake,Brenda F. Leake,Edna F. Choo,Edna F. Choo,George K. Dresser,George K. Dresser,Samir V. Kubba,Samir V. Kubba,Ute I. Schwarz,Ute I. Schwarz,Amanda Taylor,Amanda Taylor,H. G. Xie,H. G. Xie,Joel McKinsey,Joel McKinsey,Sheng Zhou,Sheng Zhou,Lu-Bin Lan,Lu-Bin Lan,John D. Schuetz,John D. Schuetz,Erin G. Schuetz,Erin G. Schuetz,Grant R. Wilkinson,Grant R. Wilkinson +27 more
TL;DR: Allelic variation in MDR1 is more common than previously recognized and involves multiple SNPs whose allelic frequencies vary between populations, and some of these SNPs are associated with altered P‐glycoprotein function.
Journal ArticleDOI
Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition
TL;DR: The clinical importance of any drug interaction depends on factors that are drug-, patient- and administration-related and is likely to be dependent on interindividual differences in CYP3A4 tissue content, pre-existing medical conditions and, possibly, age.
Journal ArticleDOI
The 2015 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension.
Kaberi Dasgupta,Robert R. Quinn,Kelly B. Zarnke,Doreen M. Rabi,Pietro Ravani,Stella S. Daskalopoulou,Simon W. Rabkin,Luc Trudeau,Ross D. Feldman,Lyne Cloutier,Ally P.H. Prebtani,Robert J. Herman,Simon L. Bacon,Richard E. Gilbert,Marcel Ruzicka,Donald W. McKay,Tavis S. Campbell,Steven A. Grover,George Honos,Ernesto L. Schiffrin,Peter Bolli,Thomas W. Wilson,Patrice Lindsay,Michael D. Hill,Shelagh B. Coutts,Gord Gubitz,Mark Gelfer,Michel Vallée,G. V. Ramesh Prasad,Marcel Lebel,Donna McLean,J. Malcolm O. Arnold,Gordon W. Moe,Jonathan G. Howlett,Jean-Martin Boulanger,Pierre Larochelle,Lawrence A. Leiter,Charlotte Jones,Richard I. Ogilvie,Vincent Woo,Janusz Kaczorowski,Kevin D. Burns,Robert J. Petrella,Swapnil Hiremath,Alain Milot,James A. Stone,Denis Drouin,Kim L. Lavoie,Maxime Lamarre-Cliche,Guy Tremblay,Pavel Hamet,George Fodor,S. George Carruthers,George Pylypchuk,Ellen Burgess,Richard Lewanczuk,George K. Dresser,S. Brian Penner,Robert A. Hegele,Philip A. McFarlane,Milan Khara,Andrew L. Pipe,Paul Oh,Peter Selby,Mukul Sharma,Debra Reid,Sheldon W. Tobe,Raj Padwal,Luc Poirier +68 more
TL;DR: The Canadian Hypertension Education Program reviews the hypertension literature annually and provides detailed recommendations regarding hypertension diagnosis, assessment, prevention, and treatment, and 4 new recommendations were added and 2 existing recommendations were modified this year.
Journal ArticleDOI
Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.
George K. Dresser,George K. Dresser,George K. Dresser,D. G. Bailey,D. G. Bailey,D. G. Bailey,Brenda F. Leake,Brenda F. Leake,Brenda F. Leake,Ute I. Schwarz,Ute I. Schwarz,Ute I. Schwarz,Paul A. Dawson,Paul A. Dawson,Paul A. Dawson,David J. Freeman,David J. Freeman,David J. Freeman,Richard B. Kim,Richard B. Kim,Richard B. Kim +20 more
TL;DR: The objective was to examine the effect of different fruits and their constituents on P‐glycoprotein and organic anion transporting polypeptide activities in vitro and on drug disposition in humans.
Journal ArticleDOI
Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children
Kara Nerenberg,Kelly B. Zarnke,Alexander A. Leung,Kaberi Dasgupta,Sonia Butalia,Kerry McBrien,Kevin C. Harris,Meranda Nakhla,Lyne Cloutier,Mark Gelfer,Maxime Lamarre-Cliche,Alain Milot,Peter Bolli,Guy Tremblay,Donna McLean,Raj Padwal,Karen C. Tran,Steven A. Grover,Simon W. Rabkin,Gordon W. Moe,Jonathan G. Howlett,Patrice Lindsay,Michael D. Hill,Mike Sharma,Thalia S. Field,Theodore Wein,Ashkan Shoamanesh,George K. Dresser,Pavel Hamet,Robert J. Herman,Ellen Burgess,Steven E. Gryn,Jean Grégoire,Richard Lewanczuk,Luc Poirier,Tavis S. Campbell,Ross D. Feldman,Kim L. Lavoie,Ross T. Tsuyuki,George Honos,Ally P.H. Prebtani,Gregory A. Kline,Ernesto L. Schiffrin,Andrew C. Don-Wauchope,Sheldon W. Tobe,Richard E. Gilbert,Lawrence A. Leiter,Charlotte Jones,Vincent Woo,Robert A. Hegele,Peter Selby,Andrew L. Pipe,Philip A. McFarlane,Paul Oh,Milan Gupta,Simon L. Bacon,Janusz Kaczorowski,Luc Trudeau,Norman R.C. Campbell,Swapnil Hiremath,Michael Roerecke,JoAnne Arcand,Marcel Ruzicka,G. V. Ramesh Prasad,Michel Vallée,Cedric Edwards,Praveena Sivapalan,S. Brian Penner,Anne Fournier,Geneviève Benoit,Janusz Feber,Janis M. Dionne,Laura A. Magee,Alexander G. Logan,Anne-Marie Côté,Evelyne Rey,Tabassum Firoz,Laura M. Kuyper,Jonathan Y. Gabor,Raymond R. Townsend,Doreen M. Rabi,Doreen M. Rabi,Stella S. Daskalopoulou +82 more
TL;DR: All individuals with hypertension should have an assessment of global cardiovascular risk to promote health behaviours that lower blood pressure, and an angiotensin receptor-neprilysin inhibitor combination should be used in place of either an ang Elliotensin-converting enzyme inhibitor or angiotENSin receptor blocker in individuals with heart failure.