▪ Abstract The prefrontal cortex has long been suspected to play an important role in cognitive control, in the ability to orchestrate thought and action in accordance with internal goals. Its neural basis, however, has remained a mystery. Here, we propose that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task. We review neurophysiological, neurobiological, neuroimaging, and computational studies that support this theory and discuss its implications as well as further issues to be addressed

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An integrative theory of prefrontal cortex function

Publisher Summary This chapter focuses on the modern notion of short-term memory, called working memory. Working memory refers to the temporary maintenance of information that was just experienced or just retrieved from long-term memory but no longer exists in the external environment. These internal representations are short-lived, but can be maintained for longer periods of time through active rehearsal strategies, and can be subjected to various operations that manipulate the information in such a way that makes it useful for goal-directed behavior. Working memory is a system that is critically important in cognition and seems necessary in the course of performing many other cognitive functions, such as reasoning, language comprehension, planning, and spatial processing. This chapter demonstrates the functional importance of dopamine to working memory function in several ways. Elucidation of the cognitive and neural mechanisms underlying human working memory is an important focus of cognitive neuroscience and neurology for much of the past decade. One conclusion that arises from research is that working memory, a faculty that enables temporary storage and manipulation of information in the service of behavioral goals, can be viewed as neither a unitary, nor a dedicated system. Data from numerous neuropsychological and neurophysiological studies in animals and humans demonstrates that a network of brain regions, including the prefrontal cortex, is critical for the active maintenance of internal representations.

Chapter 11 Working memory

The study of age-related changes in cognitive processes is flourishing as never before, making the area an exciting one for a growing number of researchers. In addition, cognitive aging research is moving out from its traditional roots in experimental and developmental psychology -- creating increased contact with cognitive neuropsychology and cognitive neuroscience. To reflect these changes in the field, this volume includes chapters on abnormal aging, the neuroscience of aging, and applied cognitive psychology along with the core section on basic cognitive processes. While other recent compilations of research in this area have given relatively brief overviews of the literature, the contributors were given space to review each topic in depth, asked to evaluate the field -- not simply their own contributions -- and to provide critical commentaries from their personal perspectives. Couched most often in terms of cognitive or information-processing models, the general perspective of the contributors is a biologically-based account of aging. This shared viewpoint gives the volume particular coherence in its treatment of theories and data. Topics covered include age differences in attention, perception, memory, knowledge representation, reasoning, and language as well as their neuropsychological and neurological correlates and practical implications.

The handbook of aging and cognition

We provide an “executive-attention” framework for organizing the cognitive neuroscience research on the constructs of working-memory capacity (WMC), general fluid intelligence, and prefrontal cortex (PFC) function. Rather than provide a novel theory of PFC function, we synthesize a wealth of singlecell, brain-imaging, and neuropsychological research through the lens of our theory of normal individual differences in WMC and attention control (Engle, Kane, & Tuholski, 1999; Engle, Tuholski, Laughlin, & Conway, 1999). Our critical review confirms the prevalent view that dorsolateral PFC circuitry is critical to executive-attention functions. Moreover, although the dorsolateral PFC is but one critical structure in a network of anterior and posterior “attention control” areas, it does have a unique executiveattention role in actively maintaining access to stimulus representations and goals in interference-rich contexts. Our review suggests the utility of an executive-attention framework for guiding future research on both PFC function and cognitive control.

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The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: An individual-differences perspective

https://autismtruths.org/pdf/SimonBaronCohen_The%20extreme-male-brain%20theory%20of%20autism.pdf

The extreme male brain theory of autism

https://www.owenlab.uwo.ca/pdf/1990-Owen-Neuropsychologia-PLANNING%20AND%20SPATIAL%20WORKING%20MEMORY%20FOLLOWING%20FRONTAL%20LOBE%20LESIONS%20IN%20MAN.pdf

Planning and spatial working memory following frontal lobe lesions in man.

Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson's disease: Evidence for a specific attentional dysfunction

The higher level cognitive function of planning was studied in a group of medicated Parkinson's disease patients and a group of matched control subjects, using a computerised version of Shallice's Tower of London task. Baseline measurement of the ability to execute a given plan of action, to generate low level strategies required for efficient searching, and spatial working memory capacity, all of which contribute to performance on the planning task, established that the Parkinson's disease group was unimpaired on any of these measures. On the Tower of London task, the Parkinson's disease group was also unimpaired in terms of the average number of moves required to solve a problem. However, a specific planning deficit was evident when "thinking" times were analysed, and this was after the confounding influence of motor initiation and execution times had been carefully extracted from total performance times. This finding is discussed in relation to putative functions of the frontal lobes and basal ganglia, and an attention-switching hypothesis is developed to account for it.

https://jnnp.bmj.com/content/jnnp/51/6/757.full.pdf

J J Downes

Papers

Planning and spatial working memory following frontal lobe lesions in man.

Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson's disease: Evidence for a specific attentional dysfunction

Planning and spatial working memory in Parkinson's disease.

Sparing of attentional relative to mnemonic function in a subgroup of patients with dementia of the Alzheimer type.