Journal ArticleDOI
Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson's disease: Evidence for a specific attentional dysfunction
J J Downes,Angela C. Roberts,Barbara J. Sahakian,J. L. Evenden,Robin G. Morris,Trevor W. Robbins +5 more
Reads0
Chats0
TLDR
The results of the first experiment showed a selective deficit in both groups of Parkinsonian subjects in their ability to perform an extra-dimensional shift and in the visual search task, the patients were less accurate, but responded with equivalent choice reaction times to those of controls.About:
This article is published in Neuropsychologia.The article was published on 1989-01-01. It has received 540 citations till now. The article focuses on the topics: Visual search.read more
Citations
More filters
Journal ArticleDOI
The extreme male brain theory of autism
TL;DR: It is suggested that two neglected dimensions for understanding human sex differences are 'empathising' and 'systemising', which can be considered as an extreme of the normal male profile of autism.
Journal ArticleDOI
Development of cognitive control and executive functions from 4 to 13 years: Evidence from manipulations of memory, inhibition, and task switching
TL;DR: This is one of the first studies, in children or adults, to explore: (a) how memory requirements interact with spatial compatibility and (b) spatial incompatibility effects both with stimulus-specific rules (Simon task) and with higher-level, conceptual rules.
Journal ArticleDOI
Multiple Dopamine Functions at Different Time Courses
TL;DR: Dopamine is involved in mediating the reactivity of the organism to the environment at different time scales, from fast impulse responses related to reward via slower changes with uncertainty, punishment, and possibly movement to the tonic enabling of postsynaptic motor, cognitive, and motivational systems deficient in Parkinson's disease.
Journal ArticleDOI
Dissociable Deficits in the Decision-Making Cognition of Chronic Amphetamine Abusers, Opiate Abusers, Patients with Focal Damage to Prefrontal Cortex, and Tryptophan-Depleted Normal Volunteers: Evidence for Monoaminergic Mechanisms
Robert D. Rogers,Barry J. Everitt,Alex Baldacchino,Alison J. Blackshaw,Rachel Swainson,Katie Wynne,N B Baker,J.E. Hunter,T. Carthy,E Booker,M. London,John Francis William Deakin,Barbara J. Sahakian,Trevor W. Robbins +13 more
TL;DR: It is suggested that chronic amphetamine abusers show similar decision-making deficits to those seen after focal damage to orbitofrontal PFC, which may reflect altered neuromodulation of the orbitof prefrontal PFC and interconnected limbic-striatal systems by both the ascending 5-HT and mesocortical dopamine projections.
Journal ArticleDOI
Dopamine and the regulation of cognition and attention
TL;DR: DA has to be considered as a key neuroregulator which contributes to behavioral adaptation and to anticipatory processes necessary for preparing voluntary action consequent upon intention, and it can be suggested that a correlation exists between DA innervation and expression of cognitive capacities.
References
More filters
Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Development and validation of a geriatric depression screening scale: A preliminary report
Jerome A. Yesavage,T. L. Brink,Terence L. Rose,Owen Lum,Virginia Huang,Michael Adey,Von O. Leirer +6 more
TL;DR: A new Geriatric Depression Scale (GDS) designed specifically for rating depression in the elderly was tested for reliability and validity and compared with the Hamilton Rating Scale for Depression (HRS-D) and the Zung Self-Rating Depression Scale(SDS) as discussed by the authors.
Journal ArticleDOI
Parkinsonism: Onset, progression, and mortality
Margaret M. Hoehn,Melvin D. Yahr +1 more
TL;DR: Controversy over the effectiveness of therapeutic measures for parkinsonism is due partially to this wide variability and to the paucity of clinical information about the natural history of the syndrome.
Journal ArticleDOI
A feature-integration theory of attention
Anne Treisman,Garry A. Gelade +1 more
TL;DR: A new hypothesis about the role of focused attention is proposed, which offers a new set of criteria for distinguishing separable from integral features and a new rationale for predicting which tasks will show attention limits and which will not.