J
J.-J. Mermod
Researcher at Biogen Idec
Publications - 3
Citations - 627
J.-J. Mermod is an academic researcher from Biogen Idec. The author has contributed to research in topics: Haematopoiesis & Colony-stimulating factor. The author has an hindex of 3, co-authored 3 publications receiving 621 citations.
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Journal Article
Hemopoietic responses in mice injected with purified recombinant murine GM-CSF.
Donald Metcalf,C G Begley,DJ Williamson,Edouard C. Nice,De Lamarter J,J.-J. Mermod,D. R. Thatcher,Schmidt A +7 more
TL;DR: The data indicate that the injection of rGM-CSF to normal mice increases overall numbers of granulocytes and macrophage and the phagocytic activity of macrophages and provides direct evidence for the conclusion that GM- CSF is likely to function in vivo as a regulator of these cell populations.
Journal ArticleDOI
Purification and properties of bacterially synthesized human granulocyte-macrophage colony stimulating factor
Antony W. Burgess,Colin Glenn Begley,Gregory R. Johnson,Angel F. Lopez,D J Williamson,J.-J. Mermod,Richard J. Simpson,A Schmitz,JF DeLamarter +8 more
TL;DR: Human granulocyte-macrophage colony stimulating factor (GM-CSF) has been synthesized in high yield using a temperature inducible plasmid in Escherichia coli and increased N-formyl-methionyl-leucyl- phenylalanine (FMLP)-induced superoxide production and lysozyme secretion.
Journal ArticleDOI
In vitro actions on hemopoietic cells of recombinant murine GM-CSF purified after production in Escherichia coli: comparison with purified native GM-CSF.
D. Metcalf,Antony W. Burgess,Gregory R. Johnson,Nicos A. Nicola,Edouard C. Nice,JF DeLamarter,D. R. Thatcher,J.-J. Mermod +7 more
TL;DR: The demonstration that purified bacterially synthesized GM‐CSF is biologically active in vitro now permits studies to be undertaken on the in vivo effects of this material.