Showing papers in "Blood in 1987"

TL;DR: The HL-60 cell line, derived from a single patient with acute promyelocytic leukemia, provides a unique in vitro model system for studying the cellular and molecular events involved in the proliferation and differentiation of normal and leukemic cells of the granulocyte/monocyte/macrophage lineage.

TL;DR: A large cohort of infants studied consecutively in the postnatal period allowed us to determine the normal development of the human coagulation system in the full-term infant and found that near-adult values are achieved for most components by 6 months of life.

TL;DR: This data indicates that the plasminogen activator inhibitor acts as a “spatially aggregating force” to knock down the number of protease-nexin-likeaques in the blood stream.

TL;DR: The results suggest that the prevalence of von Willebrand's disease (vWd) might be much higher than previously reported and that a different screening approach might be of use for patients with mild bleeding diathesis.

TL;DR: There may be a subset of symptomatic vWd patients with decreased concentrations of structurally normal vWf (vWd, type I) on the basis of blood group O, and some individuals ofBlood group AB with a genetic defect of vWF may have the diagnosis overlooked because vWF levels are elevated due to blood type.

TL;DR: A new assay is described that takes advantage of monoclonal antibodies against major platelet membrane constituents (glycoproteins IIb/IIIa and Ib and HLA class I molecule) to investigate selectively platelet reactive antibodies against epitopes on different glycoprotein.

TL;DR: It is demonstrated that activated platelets can be reliably detected in whole blood using activation-dependent monoclonal antibodies and flow cytometry and may be useful to assess the degree of platelet activation and the efficacy of antiplatelet therapy in clinical disorders.

TL;DR: Earlier in vitro findings of the critical role of the membrane glycoprotein complex, CD18, in PMN adherence and chemotaxis are confirmed and extended.

TL;DR: Three-year actuarial relapse-free survival in both standard-risk and high- risk groups compares favorably with that reported with total body irradiation (TBI) containing regimens.

TL;DR: Data illustrate that multiparameter flow cytometry can be used to define a continuous progression of stages of B lymphocyte development based on cell surface antigen expression even though these cells represent a minor fraction of normal marrow cells.

TL;DR: Evidence shows that transfer of specific immunity from marrow donors to marrow recipients plays a role in reestablishing immunocompetence, which may explain why more recipients do not die from overwhelming infections.

TL;DR: It is demonstrated that high doses of 1F5 can be administered to patients with negligible toxicity by continuous infusion and that clinical responses can be obtained in patients given greater than 1 g of unmodified antibody over a ten-day period.

TL;DR: Investigations suggest that these assay techniques can be used to improve the understanding of the hypercoagulable state as well as to develop more effective treatment strategies for the prevention of thromboembolic events.

TL;DR: This review summarizes the current knowledge on vWF and vWD, and identifies the regions of the molecule that interact with factor VIII, heparin, the glycoprotein lb of platelets, and collagen.

TL;DR: The von Willebrand factor (vWF) is a multimeric glycoprotein that mediates platelet adhesion and aggregation onto thrombogenic surfaces, and functioning as carrier in plasma for the factor VIII procoagulant protein this paper.

TL;DR: The relationship between inhibition of platelet capacity to form thromboxane ex vivo (serum TxB2) and synthesis in vivo (Tx-M) departed markedly from the line of identity.

TL;DR: The effect of flow on PMNL adhesion appears to be an important factor in determining the outcome of the PMNL/HUVEC adhesive interaction under these experimental conditions.

TL;DR: Flow cytometry was used to identify maturational differences of erythroid lineage cells in normal human bone marrow by combining physical characteristics, the expression of multiple cell surface antigens, and nucleic acid content, and Decreases in cellular nucleic acids content, corresponding first to the extrusion of the nucleus and second to the loss of reticulum, characterized the later stages of ERYthroid development.

TL;DR: The results suggest that GM-CSF may be an endogenous regulator of neutrophil inflammatory responses induced by the major physiological chemoattractants.

TL;DR: It is demonstrated that during pregnancy and in the puerperium profound alterations of the fibrinolytic system occur that are characterized by increases in PAs and their inhibitors, but these alterations do not affect the overall fibralelytic activity.

TL;DR: Although there was a transient increase in the relapse rate for patients who discontinued therapy, the proportion of long-term remitters was identical in the two patient groups and there is a suggestion of a survival advantage for patients randomized to discontinue all therapy at 8 months.

TL;DR: It is concluded that human leukocyte alpha interferon effectively controls chronic myeloid leukemia and allows reappearance of diploid hemopoietic cells in some patients.

TL;DR: It is concluded that clinically adaptable assays allow detection of autoantibodies in most patients with chronic ITP, confirming the presence of an autoimmune process.

TL;DR: The experiments demonstrate that vWF-platelet interactions can occur in the absence of artificial agonists or chemical modification of vWF, and suggest a possible mechanism for platelet aggregation in stenosed or partially obstructed arterial vessels in which the platelets are subjected to relatively high levels of shear stress.

TL;DR: Results indicated that platelet aggregation by the patient's IgG was induced by the reaction of an antibody with a specific antigen on the normal platelet membrane through stimulus-response coupling.

TL;DR: The results suggest that there is considerable overlap between the GM-CSF- and G- CSF-responsive AML-CFU subpopulations in most cases, and that the combination of these factors could replace a leukocyte feeder layer in providing maximum growth stimulation.

TL;DR: In vivo platelet activation was studied in patients undergoing cardiac surgery with cardiopulmonary bypass and in patients with acute deep venous thrombosis, indicating that 2.28 may serve as a useful probe of in vitro and in vivo platelets activation.