J. Klosterkoetter

TL;DR: A 54-year-old patient with a severe anxiety disorder and secondary depressive disorder in whom bilateral deep brain stimulation of the nucleus accumbens was carried out observes a remarkable although not primarily intended alleviation of the patient’s comorbid alcohol dependency.

TL;DR: Sensory gating is already impaired in early stages of schizophrenia, though this is most prominent in chronic stages, and future studies will have to clarify the type and impact of variables modifying sensory gating disturbances, such as illness progression and genetic load.

TL;DR: A 26 year old male patient suffering from a serious Tourette Syndrome showed a significant reduction in both the frequency and gravity of his tics over the course of a two and half year observation period under application of deep brain stimulation (DBS).

TL;DR: Albeit the results of the study are severely limited by the method of retrospective self-assessment of psychiatric patients, further research of DBS of the NAc to treat addiction seems justified.

TL;DR: A broad effect on cognition is consistent with ample experimental evidence revealing that the nucleus basalis of Meynert provides cholinergic innervation to the cortical mantle, complemented by glutaminergic and gamma-aminobutyric acid-transmitting projections from the basal forebrain.