J. M. Angles

TL;DR: A Nomenclature Committee for factors of the dog major histocompatibility system or dog leukocyte antigen (DLA) has been convened under the auspices of the International Society for Animal Genetics (ISAG) to define a sequence-based nomenclatures for the genes of the DLA system as discussed by the authors.

TL;DR: The high interbreed, and relatively low intrabreed, variation of MHC alleles and haplotypes found in this study could provide an explanation for reports of interbree variation of immune responses to vaccines, viruses and other infections.

TL;DR: It is suggested that a conserved amino acid motif in the 3HVR present in some DRB1 alleles of both dogs and humans is associated with rheumatoid arthritis in both species.

TL;DR: A Nomenclature Committee for factors of the dog major histocompatibility system or dog leukocyte antigen (DLA) has been convened under the auspices of the International Society for Animal Genetics (ISAG) to define a sequence-based nomenclatures for the genes of the DLA system.

TL;DR: The wolves studied had relatively few dog DLA alleles and may therefore represent a remnant population descended from Asian wolves, suggesting that the wolf ancestors of Asian and European dogs may have had different gene pools, currently reflected in the D LA alleles present in dog breeds.