Showing papers in "Gynecologic Oncology in 2000"

TL;DR: The results suggest that current screening practices in the United States are insufficient to detect a significant proportion of adenocarcinoma precursor lesions and the number of women at risk of cervical cancer has increased.

TL;DR: TVS screening does not appear to be effective in detecting ovarian cancer in which ovarian volume is normal, and when performed annually, is associated with a decreases in stage at detection and a decrease in case-specific ovarian cancer mortality.

TL;DR: Clinically significant depression and anxiety may be more prevalent in patients with EOC than previously reported and future studies of screening for and treating psychological distress are being designed to improve QOL in these women.

TL;DR: There is a statistically significant decrease in ovarian volume with each decade of life from age 30 to age 70, and mean ovarian volume in premenopausal women is significantly greater than that in post menopausal women.

TL;DR: The terms endometrial hyperplasia (EH),endometrial intraepithelial neoplasia (EIN), and adenocarcinoma are proposed to define distinctive subgroups that are functionally relevant to clinical management of patients with endometrium disease.

TL;DR: There was a statistically significant regression of CIN in patients treated with I-3-C orally compared with placebo, and the 2/16 alpha-hydroxyestrone ratio changed in a dose-dependent fashion.

TL;DR: Ovarian carcinomas, especially clear cell and endometrioid adenocarcinomas, are highly associated with endometRIosis, suggesting it is a precancerous status.

TL;DR: The addition of cisplatin to ifosfamide appears to offer a small improvement in progression-free survival over ifosFamide alone in the management of advanced carcinosarcoma of the uterus; the added toxicity may not justify the use of this combination.

TL;DR: Most obese women with early stage endometrial cancer can be safely managed through laparoscopy with excellent surgical outcome, shorter hospitalization, and less postoperative pain than those managed by laparotomy.

TL;DR: A potential therapeutic role for formal PAL in endometrial cancer is suggested in patients at high risk for para-aortic lymph node involvement and in patients with positive nodes.

TL;DR: Patients with IP, IEPUA, or CCA have a poorer prognosis than patients with IEP; and patients with clitoral Paget's disease may require more aggressive treatment.

TL;DR: If the sensitivity of the assessment of the BDLN is confirmed to be 100%, this laparoscopic approach could transform the management of early cervical cancer.

TL;DR: The probability of performing optimal cytoreduction in patients with Stage III ovarian carcinoma and a preoperative CA-125 greater than 500 U/ml was approximately one in five, which may be candidates for initial laparoscopic evaluation to obtain a confirmatory tissue diagnosis and to determine resectability.

TL;DR: Using the middle rectal artery as a landmark the neural part of the cardinal ligament can be preserved, resulting in preservation of the motor function of the bladder.

TL;DR: Constitutive activation of Stat 3 is present in ovarian cancer lines but not in normal ovarian surface epithelial cells, and the relationship of this aberrancy of ovarian carcinoma harboring activated Stat 3 deserves further investigation.

TL;DR: Findings provide the first molecular evidence that Fallopian tube cancer may be due to germline mutations in BRCA1, and may have important consequences for the preferred method of prophylactic oophorectomy in B RCA1 mutation carriers.

TL;DR: Posttherapy surveillance programs are directed toward asymptomatic patients in whom early detection of recurrence may impact survival, indicating that a subset of women may benefit from surveillance.

TL;DR: Biases and ethical issues based upon the data cited in this paper have and will continue to hamper the ability to fully elaborate the benefits of surgery with respect to survival and quality of life.

TL;DR: Anastrozole has minimal activity in an unselected population of patients with recurrent endometrial cancer and the toxicity profile was mild.

TL;DR: Evaluation of endometrial histopathologic findings from 700 patients treated with tamoxifen for breast cancer from two medical centers found Endometrial polyps, hyperplasia and metaplasia, consistent with an estrogen-agonist effect of Tx, were found in roughly one-third of all patients.

TL;DR: Recurrences are more frequent among PS and CC tumors compared withEM and among PS compared with EM3, and prospective trials of aggressive adjuvant therapies for surgical stage I-II tumors are needed to improve outcome.

TL;DR: Whether HPV DNA is persistently detected in the cervix after therapeutic conization for CIN 3 and whether a patient with persistence of HPV infection is at risk of developing recurrent disease is explored.

TL;DR: Systematic paraaortic lymphadenectomy by a left extraperitoneal route is feasible and provides the advantages related to the use of the extraperizenal route while reducing manipulations and thus the risk of peritoneal tearing compared to those of the bilateral extraperitonal route.

TL;DR: The amount of residual disease after cytoreductive surgery, age, and performance status appear to be important determinants of survival in patients with Stage IVB endometrial carcinoma.

TL;DR: The results present a challenge to health care providers in more adequately meeting the individual information needs of women with ovarian cancer and involving them to the extent that they wish in the decision-making process.

TL;DR: This modified liposomal doxorubicin regimen results in less toxicity (stomatitis, hand-foot syndrome) than the standard FDA-approved dose schedule and definite, although limited, antineoplastic activity is observed in patients with well-defined platinum- and paclitaxel-refractory ovarian cancer.

TL;DR: The results suggest that the expression of COX-2 in stage IB cervical cancer may downregulate apoptotic processes and thus enhance tumor invasion and metastasis.

TL;DR: Although sentinel node pathology was representative of the lymphatic basin sampled in all cases, the rate of SLN identification was low with this technique, and lymphatic dye uptake appears to be less reliable in patients with larger tumors.

TL;DR: The steady decline of FSHR expression from benign cystadenoma to borderline tumor to carcinoma suggests that FSH may be needed in early ovarian cancer development.

TL;DR: Age, depression, worsening GOG performance status, and preoperative hypoactive sexual dysfunction were risk factors for sexual dysfunction after vulvar surgery, and Appropriate counseling and treatment of depression may be of benefit to this patient population.