J P Idström

TL;DR: Eradication of Helicobacter pylori provides potential cure in the majority of patients with peptic ulcer disease, and eradication rates of more than 90% have been reported, using omeprazole in combination with two antimicrobials.

TL;DR: In patients with duodenal ulcers treated with omeprazole, intragastric pH depends significantly on the presence or absence of H. pylori, whereas baseline pH remained unchanged after H.pylori eradication.

TL;DR: The data indicate that omeprazole produces a greater decrease in gastric acidity in subjects with H pylori infection than in those who are Hpylori negative, and it is not, however, known whether there is a causal relationship between H plyori infection and increased omepazole efficacy.

TL;DR: It is concluded that the apparently greater antisecretory effect of omeprazole during H pylori infection may be a result of the production of acid neutralising compounds by the H plyori.

TL;DR: It is concluded that omeprazole (20 mg once daily for two weeks in healthy volunteers is associated with gastric bacterial proliferation but does not increase concentrations of N-nitroso compounds.