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Brigitte Pignatelli
Researcher at International Agency for Research on Cancer
Publications - 58
Citations - 3281
Brigitte Pignatelli is an academic researcher from International Agency for Research on Cancer. The author has contributed to research in topics: Nitrosation & Nitrite. The author has an hindex of 30, co-authored 58 publications receiving 3213 citations. Previous affiliations of Brigitte Pignatelli include Centre national de la recherche scientifique.
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Journal ArticleDOI
Bacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomised double blind study.
J Thorens,F. Froehlich,Werner Schwizer,E. Saraga,J Bille,K Gyr,P. Duroux,M. Nicolet,Brigitte Pignatelli,A. L. Blum,J J Gonvers,Michael Fried +11 more
TL;DR: The results show that the incidence of gastric and duodenal bacterial overgrowth is considerably higher in patients treated with omeprazole compared with cimetidine, which can be explained by more pronounced inhibition of Gastric acid secretion.
Journal ArticleDOI
Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer?
Sheila Bingham,Brigitte Pignatelli,J.R.A. Pollock,Anne Ellul,Christian Malaveille,G. Gross,S. A. Runswick,John H. Cummings,I.K. O'Neill +8 more
TL;DR: Increased endogenous production of NOC and precursors from increased red meat, but not white meat and fish, consumption may be relevant to the aetiology of colorectal cancer.
Journal ArticleDOI
Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro
Vladimir Yermilov,Julieta Rubio,Michel Becchi,Marlin D. Friesen,Brigitte Pignatelli,Hiroshi Ohshima +5 more
TL;DR: 8-Nitroguanine could act as a specific marker for DNA damage induced by peroxynitrite in inflamed tissues, contributing to the multistage carcinogenesis process.
Journal ArticleDOI
Inhibitors of endogenous nitrosation. Mechanisms and implications in human cancer prevention.
TL;DR: The chemistry of NOC formation and inhibition, the studies in experimental animals which showed that inhibition of endogenous NOC synthesis leads to a reduction of toxic, mutagenic and carcinogenic effects, and the contribution of nitrosation inhibitors to human cancer prevention are reviewed.
Journal Article
Nitrated and Oxidized Plasma Proteins in Smokers and Lung Cancer Patients
Brigitte Pignatelli,Chun-Qi Li,Paolo Boffetta,Qiping Chen,Wolfgang Ahrens,Fredrik Nyberg,Anush Mukeria,Irene Brüske-Hohlfeld,Cristina Fortes,Vali Constantinescu,Harry Ischiropoulos,Hiroshi Ohshima +11 more
TL;DR: The results indicate that cigarette smoking increases oxidative stress and that during lung cancer development, formation of reactive nitrogen species results in nitration and oxidation of plasma proteins.