J.-P. Laigneau

TL;DR: It is shown that leptin messenger RNA and leptin protein are present in rat gastric epithelium, and that cells in the glands of the gastric fundic mucosa are immunoreactive for leptin, indicating that gastric leptin may be involved in early CCK-mediated effects activated by food intake, possibly including satiety.

TL;DR: These data provide the first evidence of the presence of leptin and leptin receptor proteins in the human stomach and suggest that gastric epithelial cells may be direct targets for leptin.

TL;DR: The findings do not support a pivotal role for hyperleptinaemia in intestinal carcinogenesis and leptin acts as a growth factor on colon cancer cells in vitro but does not promote tumour growth in vivo in the two models tested.

TL;DR: This study provides the first evidence that leptin reduces the development of chemically induced precancerous lesions in colon, perhaps through decreased insulinemia, and thus does not support an important role for leptin in carcinogenesis promotion.

TL;DR: Data argue for a physiological role for the cholecystokinin or its structurally related peptide gastrin in long term regulation of adipocyte leptin secretion, and suggest a role for gastrin/CCK-B receptor mRNA, but not CCK-A receptor mRNA.