Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease. OCT is an interferometric technique that detects reflected and backscattered light from tissue and is often described as the optical analogue to ultrasound. The inherent safety of the technology allows for in vivo use of OCT in patients. The main strength of OCT is the depth resolution. In dermatology, most OCT research has turned on non-melanoma skin cancer (NMSC) and non-invasive monitoring of morphological changes in a number of skin diseases based on pattern recognition, and studies have found good agreement between OCT images and histopathological architecture. OCT has shown high accuracy in distinguishing lesions from normal skin, which is of great importance in identifying tumour borders or residual neoplastic tissue after therapy. The OCT images provide an advantageous combination of resolution and penetration depth, but specific studies of diagnostic sensitivity and specificity in dermatology are sparse. In order to improve OCT image quality and expand the potential of OCT, technical developments are necessary. It is suggested that the technology will be of particular interest to the routine follow-up of patients undergoing non-invasive therapy of malignant or premalignant keratinocyte tumours. It is speculated that the continued technological development can propel the method to a greater level of dermatological use.

https://link.springer.com/content/pdf/bfm%3A978-3-319-06419-2%2F1.pdf

Optical Coherence Tomography

We review the field of femtosecond pulse shaping, in which Fourier synthesis methods are used to generate nearly arbitrarily shaped ultrafast optical wave forms according to user specification. An emphasis is placed on programmable pulse shaping methods based on the use of spatial light modulators. After outlining the fundamental principles of pulse shaping, we then present a detailed discussion of pulse shaping using several different types of spatial light modulators. Finally, new research directions in pulse shaping, and applications of pulse shaping to optical communications, biomedical optical imaging, high power laser amplifiers, quantum control, and laser-electron beam interactions are reviewed.

Femtosecond pulse shaping using spatial light modulators

There have been three basic approaches to optical tomography since the early 1980s: diffraction tomography, diffuse optical tomography and optical coherence tomography (OCT). Optical techniques are of particular importance in the medical field, because these techniques promise to be safe and cheap and, in addition, offer a therapeutic potential. Advances in OCT technology have made it possible to apply OCT in a wide variety of applications but medical applications are still dominating. Specific advantages of OCT are its high depth and transversal resolution, the fact, that its depth resolution is decoupled from transverse resolution, high probing depth in scattering media, contact-free and non-invasive operation, and the possibility to create various function dependent image contrasting methods. This report presents the principles of OCT and the state of important OCT applications. OCT synthesises cross-sectional images from a series of laterally adjacent depth-scans. At present OCT is used in three different fields of optical imaging, in macroscopic imaging of structures which can be seen by the naked eye or using weak magnifications, in microscopic imaging using magnifications up to the classical limit of microscopic resolution and in endoscopic imaging, using low and medium magnification. First, OCT techniques, like the reflectometry technique and the dual beam technique were based on time-domain low coherence interferometry depth-scans. Later, Fourier-domain techniques have been developed and led to new imaging schemes. Recently developed parallel OCT schemes eliminate the need for lateral scanning and, therefore, dramatically increase the imaging rate. These schemes use CCD cameras and CMOS detector arrays as photodetectors. Video-rate three-dimensional OCT pictures have been obtained. Modifying interference microscopy techniques has led to high-resolution optical coherence microscopy that achieved sub-micrometre resolution. This report is concluded with a short presentation of important OCT applications. Ophthalmology is, due to the transparent ocular structures, still the main field of OCT application. The first commercial instrument too has been introduced for ophthalmic diagnostics (Carl Zeiss Meditec AG). Advances in using near-infrared light, however, opened the path for OCT imaging in strongly scattering tissues. Today, optical in vivo biopsy is one of the most challenging fields of OCT application. High resolution, high penetration depth, and its potential for functional imaging attribute to OCT an optical biopsy quality, which can be used to assess tissue and cell function and morphology in situ. OCT can already clarify the relevant architectural tissue morphology. For many diseases, however, including cancer in its early stages, higher resolution is necessary. New broad-bandwidth light sources, like photonic crystal fibres and superfluorescent fibre sources, and new contrasting techniques, give access to new sample properties and unmatched sensitivity and resolution.

/pdf/optical-coherence-tomography-principles-and-applications-17y32cabbm.pdf

Optical coherence tomography - principles and applications

Tailored femtosecond laser pulses from a computer-controlled pulse shaper were used to optimize the branching ratios of different organometallic photodissociation reaction channels. The optimization procedure is based on the feedback from reaction product quantities in a learning evolutionary algorithm that iteratively improves the phase of the applied femtosecond laser pulse. In the case of CpFe(CO)2Cl, it is shown that two different bond-cleaving reactions can be selected, resulting in chemically different products. At least in this case, the method works automatically and finds optimal solutions without previous knowledge of the molecular system and the experimental environment.

https://science.sciencemag.org/content/sci/282/5390/919.full.pdf

Control of Chemical Reactions by Feedback-Optimized Phase-Shaped Femtosecond Laser Pulses

Have you ever felt that the very title, Progress in Optics, conjured an image in your mind? Don’t you see a row of handsomely printed books, bearing the editorial stamp of one of the most brilliant members of the optics community, and chronicling the field of optics since the invention of the laser? If so, you are certain to move the bookend to make room for Volume 16, the latest of this series. It contains seven chapters on widely diverging topics, written by well-known authorities in their fields. These are: 1) Laser Selective Photophysics and Photochemistry by V. S. Letokhov, 2) Recent Advances in Phase Profiles (sic) Generation by J. J. Clair and C. I. Abitbol, 3 ) Computer-Generated Holograms: Techniques and Applications by W.-H. Lee, 4) Speckle Interferometry by A. E. Ennos, 5 ) Deformation  Invariant, Space-Variant Optical  Pattern Recognition by D. Casasent and D. Psaltis, 6) Light Emission from High-Current Surface-Spark Discharges by R. E. Beverly, and 7) Semiclassical Radiation  Theory within a  QuantumMechanical Framework by I. R. Senitzkt. The  breadth of topic  matter  spanned  by  these  chapters makes it impossible, for this reviewer at least, to pass judgement on the comprehensiveness, relevance, and completeness of every chapter. With an editorial board as prominent as that of Progress in Optics, however, it seems hardly likely that such comments should be necessary. It should certainly be possible to take the authority of each author as credible. The only remaining judgment to be  made on these chapters is their readability. In short, what are they like to read? The first sentence of the first chapter greets the eye with an obvious typographical error: “The creation of coherent laser light source, that have tunable radiation, opened the . . . .” Two pages later we find: “When two types of atoms or molecules of different isotopic composition ( A and B ) have even one spectral line that does not overlap with others, it is pos-

Progress in optics

Programmable shaping of femtosecond pulses by using a 128-element liquid crystal modulator to manipulate the phases of optical frequency components which are spatially dispersed within a grating-and-lens pulse shaping apparatus is described. This apparatus makes possible gray-level control of the spectral phases and allows modification of the pulse shape on a millisecond time scale under electronic control. Refinements in the design of the multielement modulator result in pulse shaping fidelity comparable to that which can be achieved with microlithographically fabricated masks. Several examples of pulse shaping operation, including pulse position modulation, programmable pulse compression, and adjustable cubic phase distortion, are described. >

Programmable shaping of femtosecond optical pulses by use of 128-element liquid crystal phase modulator

We report programmable shaping of femtosecond optical pulses by use of a multielement liquid-crystal modulator to manipulate the phases of spatially dispersed optical frequency components. Our approach provides for continuously variable control of the optical phase and permits the pulse shape to be reconfigured on a millisecond time scale. We use the apparatus to demonstrate femtosecond pulse-position modulation as well as programmable compression of chirped femtosecond pulses.

/pdf/programmable-femtosecond-pulse-shaping-by-use-of-a-1rfa3kubhk.pdf

Programmable femtosecond pulse shaping by use of a multielement liquid-crystal phase modulator.

An instant messaging communication system wherein users can obtain instant messaging at different terminal devices, in accordance with information they priorly store in a user defined terminal selection store in a unified instant messaging processor. The unified instant messaging processor also stores user preference data. Data from users arrives at the unified instant messaging processor directly over the internet, while an instant messaging client communicates with the unified instant messaging processor through a presence and messaging processor. The data may include either message data or presence data, and a processor in the unified instant message processor determines the handling of the data, with reference to information prior stored by a user, and enables appropriate formatting and routing of the information.

Local presence state and user-controlled presence and message forwarding in unified instant messaging

Coupling of two‐dimensional (2D) vertical‐cavity surface‐emitting lasers (VCSELs) to give a coherent supermode is described. The top metal layer of a stained‐layer InGaAs quantum well VCSEL structure was patterned laterally by depositing various metals with different optical reflectivities. This lateral reflectivity patterning defined a 2D laser array sharing the same ‘‘supercavity’’. It is shown that these 2D arrays oscillate in a stable single, coherent 2D supermode. This was achieved with a simple planar process and without significant deterioration of threshold current and efficiency relative to an equivalent broad‐area VCSEL.

Two‐dimensional phase‐locked arrays of vertical‐cavity semiconductor lasers by mirror reflectivity modulation

We argue that pervasive computing offers not only tremendous opportunities and exciting research challenges but also possible negative environmental impacts, particularly in terms of physical waste and energy consumption. These environmental impacts will come under increasing government and consumer scrutiny, and like other disciplines (e.g. architecture, transportation), pervasive computing will have to adapt accordingly. Further, we argue that software-related issues will play an increasing role in reducing the environmental impact of computing. We thus propose that an important challenge for pervasive computing is to develop research in new architectures, design methodologies, metrics, algorithms and operating systems to minimize these impacts. We then discuss specific research issues and questions that arise in three phases of the device lifecycle: minimizing resource usage for manufacture and operation, maximizing device lifetime, and improving recyclability.

/pdf/challenges-environmental-design-for-pervasive-computing-5bsfst266n.pdf

J. R. Wullert

Papers

Programmable shaping of femtosecond optical pulses by use of 128-element liquid crystal phase modulator

Programmable femtosecond pulse shaping by use of a multielement liquid-crystal phase modulator.

Local presence state and user-controlled presence and message forwarding in unified instant messaging

Two‐dimensional phase‐locked arrays of vertical‐cavity semiconductor lasers by mirror reflectivity modulation

Challenges: environmental design for pervasive computing systems