J
J. S. H. Gaston
Researcher at University of Cambridge
Publications - 30
Citations - 1472
J. S. H. Gaston is an academic researcher from University of Cambridge. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 21, co-authored 30 publications receiving 1427 citations.
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Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
David M. Evans,C. C. A. Spencer,J J Pointon,Zhan Su,David Harvey,Grazyna Kochan,U. Opperman,Alexander T. Dilthey,Matti Pirinen,Stone,L H Appleton,L. Moutsianis,Stephen Leslie,T. W. H. Wordsworth,Tony J. Kenna,Tugce Karaderi,Gethin P. Thomas,M. M. Ward,Michael H. Weisman,C Farrar,Linda A. Bradbury,Patrick Danoy,Robert D. Inman,Walter P. Maksymowych,Dafna D. Gladman,Proton Rahman,Ann W. Morgan,Helena Marzo-Ortega,Paul Bowness,Karl Gaffney,J. S. H. Gaston,Malcolm D. Smith,Jácome Bruges-Armas,Ana Rita Couto,Rosa Sorrentino,Fabiana Paladini,Ferreira,Huji Xu,Yu Liu,L. Jiang,Carlos López-Larrea,Roberto Díaz-Peña,A. Lóepez-Vázquez,Tetyana Zayats,Céline Bellenguez,H. D. Blackburn,Jenefer M. Blackwell,Elvira Bramon,Suzannah Bumpstead,Juan P. Casas,Aiden Corvin,N. Craddock,Panagiotis Deloukas,Serge Dronov,Audrey Duncanson,Sarah Edkins,Colin Freeman,Matthew W. Gillman,Erin Gray,R. Gwilliam,Naomi Hammond,Sarah E. Hunt,Janusz Jankowski,Alagurevathi Jayakumar,Cordelia Langford,Jennifer Liddle,Hugh S. Markus,Christopher G. Mathew,O. T. McCann,Mark I. McCarthy,Colin N. A. Palmer,Leena Peltonen,Robert Plomin,Simon C. Potter,Anna Rautanen,Radhi Ravindrarajah,Michelle Ricketts,Nilesh J. Samani,Stephen Sawcer,A. Strange,Richard C. Trembath,Ananth C. Viswanathan,Matthew Waller,Paul A. Weston,Pamela Whittaker,Sara Widaa,Nicholas W. Wood,Gil McVean,John D. Reveille,B P Wordsworth,Brown,Peter Donnelly +91 more
TL;DR: This paper reported the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P -8 in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9.
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Comparison of two referral strategies for diagnosis of axial spondyloarthritis: the Recognising and Diagnosing Ankylosing Spondylitis Reliably (RADAR) study
Joachim Sieper,Shankar Srinivasan,Omid Zamani,Herman Mielants,Denis Choquette,Karel Pavelka,Anne Gitte Loft,Pál Géher,Debashish Danda,Tatiana Reitblat,Fabrizio Cantini,Codrina Ancuta,Shandor Erdes,Helena Raffayova,Andrew Keat,J. S. H. Gaston,Sonja Praprotnik,Nathan Vastesaeger +17 more
TL;DR: A referral strategy based on three criteria leads to a diagnosis of axial spondyloarthritis in approximately 35% of patients with CBP and is applicable across countries and geographical locales with presumably different levels of expertise in axial SpA.
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Three month treatment of reactive arthritis with azithromycin: a EULAR double blind, placebo controlled study
T.K. Kvien,J. S. H. Gaston,T Bardin,Irena Butrimiene,Ben A. C. Dijkmans,Marjatta Leirisalo-Repo,P Solakov,M Altwegg,P Mowinckel,P-A Plan,T Vischer +10 more
TL;DR: This large trial has demonstrated that prolonged treatment with azithromycin is ineffective in ReA, with no statistical differences for changes in any end point between the active treatment and placebo groups.
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In vitro responses of human CD45R0brightRA- and CD45R0-RAbright T cell subsets and their relationship to memory and naive T cells.
TL;DR: The data support the view that in human peripheral blood, CD45R0bright and CD45RAbright expression identify memory and naive CD4+ T cells, respectively.
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Specific lysis of mycobacterial antigen-bearing macrophages by class II MHC-restricted polyclonal T cell lines in healthy donors or patients with tuberculosis.
Dinakantha S. Kumararatne,A. S. Pithie,P. Drysdale,J. S. H. Gaston,Rolf Kiessling,P. B. Iles,C. J. Ellis,J A Innes,R. Wise +8 more
TL;DR: It is concluded that mycobacterial antigen‐specific cytotoxic T cell responses may play a significant part in the immune response to myCobacterial infection.