C
Carlos López-Larrea
Researcher at Central University, India
Publications - 175
Citations - 8618
Carlos López-Larrea is an academic researcher from Central University, India. The author has contributed to research in topics: Human leukocyte antigen & Population. The author has an hindex of 49, co-authored 163 publications receiving 7774 citations.
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Journal ArticleDOI
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
David M. Evans,Spencer Cca.,J J Pointon,Zhan Su,D Harvey,Grazyna Kochan,Udo Oppermann,Alexander T. Dilthey,Matti Pirinen,Millicent A. Stone,L H Appleton,Loukas Moutsianas,Stephen Leslie,T. W. H. Wordsworth,Tony J. Kenna,Tugce Karaderi,Gethin P. Thomas,Minghong Ward,Michael H. Weisman,C. Farrar,Linda A. Bradbury,Patrick Danoy,Robert D. Inman,Walter P. Maksymowych,Dafna D. Gladman,Proton Rahman,Ann W. Morgan,Helena Marzo-Ortega,Paul Bowness,Karl Gaffney,Gaston Jsh.,Malcolm D. Smith,Jácome Bruges-Armas,Couto A-R.,Rosa Sorrentino,Fabiana Paladini,Manuel A. R. Ferreira,Huji Xu,Yu Liu,L. Jiang,Carlos López-Larrea,Roberto Díaz-Peña,Antonio López-Vázquez,Tetyana Zayats,Céline Bellenguez,Hannah Blackburn,Jenefer M. Blackwell,Elvira Bramon,Suzannah Bumpstead,Juan P. Casas,Aiden Corvin,N. Craddock,Panagiotis Deloukas,Serge Dronov,Audrey Duncanson,Sarah Edkins,Colin Freeman,Matthew W. Gillman,Emma Gray,R. Gwilliam,Naomi Hammond,Sarah E. Hunt,Janusz Jankowski,Alagurevathi Jayakumar,Cordelia Langford,Jennifer Liddle,Hugh S. Markus,Christopher G. Mathew,O. T. McCann,Mark I. McCarthy,Palmer Cna.,Leena Peltonen,Robert Plomin,Simon C. Potter,Anna Rautanen,Radhi Ravindrarajah,Michelle Ricketts,Nilesh J. Samani,Stephen Sawcer,A. Strange,Richard C. Trembath,Ananth C. Viswanathan,Ananth C. Viswanathan,Matthew Waller,Paul A. Weston,Pamela Whittaker,Sara Widaa,Nicholas W. Wood,Gil McVean,John D. Reveille,B P Wordsworth,Matthew A. Brown,Peter Donnelly +92 more
TL;DR: In this paper, the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 x 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all their datasets (p < 5x 10(-6) overall, with support in each of the three datasets studied).
Journal ArticleDOI
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.
Adrian Cortes,Johanna Hadler,J.P. Pointon,Philip Robinson,Tugce Karaderi,Paul Leo,Katie Cremin,Karena Pryce,Jessica Harris,Sang-Gug Lee,Kyung Bin Joo,Shim S-C.,Michael H. Weisman,Minghong Ward,Xiaodong Zhou,Garchon H-J.,Gilles Chiocchia,Johannes C. Nossent,Benedicte A. Lie,Øystein Førre,J. Tuomilehto,J. Tuomilehto,J. Tuomilehto,K. Laiho,Lei Jiang,Yu Liu,Xin Wu,Linda A. Bradbury,Dirk Elewaut,Ruben Burgos-Vargas,Simon Stebbings,Louise Appleton,Claire Farrah,J. Lau,Tony J. Kenna,Nigil Haroon,Manuel A. R. Ferreira,Jian Yang,J Mulero,José Luis Fernández-Sueiro,Miguel A. Gonzalez-Gay,Carlos López-Larrea,Panagiotis Deloukas,Peter Donnelly,Paul Bowness,Karl Gafney,Hill Gaston,Dafna D. Gladman,Dafna D. Gladman,Proton Rahman,Walter P. Maksymowych,Huji Xu,Crusius Jba.,I E van der Horst-Bruinsma,Chou C-T.,R. Valle-Oñate,Consuelo Romero-Sánchez,Inger Myrnes Hansen,Fernando Pimentel-Santos,Robert D. Inman,Vibeke Videm,Javier Martín,Maxime Breban,Maxime Breban,J. D. Reveille,David M. Evans,Kim T-H.,B P Wordsworth,Matthew A. Brown +68 more
TL;DR: In this paper, the authors used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls.
Journal ArticleDOI
The Inflammatory Cytokines TWEAK and TNFα Reduce Renal Klotho Expression through NFκB
Juan Antonio Moreno,María Concepción Izquierdo,Maria Dolores Sanchez-Niño,Beatriz Suarez-Alvarez,Carlos López-Larrea,Aniela Jakubowski,Julia Ramírez Blanco,Rafael J. Ramirez,Rafael Selgas,Marta Ruiz-Ortega,Jesús Egido,Alberto Ortiz,Ana Belen Sanz +12 more
TL;DR: Inflammatory cytokines, such as TWEAK and TNFα, downregulate Klotho expression through an NFκB-dependent mechanism, which may partially explain the relationship between inflammation and diseases characterized by accelerated aging of organs, including CKD.
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
David M. Evans,C. C. A. Spencer,J J Pointon,Zhan Su,David Harvey,Grazyna Kochan,U. Opperman,Alexander T. Dilthey,Matti Pirinen,Stone,L H Appleton,L. Moutsianis,Stephen Leslie,T. W. H. Wordsworth,Tony J. Kenna,Tugce Karaderi,Gethin P. Thomas,M. M. Ward,Michael H. Weisman,C Farrar,Linda A. Bradbury,Patrick Danoy,Robert D. Inman,Walter P. Maksymowych,Dafna D. Gladman,Proton Rahman,Ann W. Morgan,Helena Marzo-Ortega,Paul Bowness,Karl Gaffney,J. S. H. Gaston,Malcolm D. Smith,Jácome Bruges-Armas,Ana Rita Couto,Rosa Sorrentino,Fabiana Paladini,Ferreira,Huji Xu,Yu Liu,L. Jiang,Carlos López-Larrea,Roberto Díaz-Peña,A. Lóepez-Vázquez,Tetyana Zayats,Céline Bellenguez,H. D. Blackburn,Jenefer M. Blackwell,Elvira Bramon,Suzannah Bumpstead,Juan P. Casas,Aiden Corvin,N. Craddock,Panagiotis Deloukas,Serge Dronov,Audrey Duncanson,Sarah Edkins,Colin Freeman,Matthew W. Gillman,Erin Gray,R. Gwilliam,Naomi Hammond,Sarah E. Hunt,Janusz Jankowski,Alagurevathi Jayakumar,Cordelia Langford,Jennifer Liddle,Hugh S. Markus,Christopher G. Mathew,O. T. McCann,Mark I. McCarthy,Colin N. A. Palmer,Leena Peltonen,Robert Plomin,Simon C. Potter,Anna Rautanen,Radhi Ravindrarajah,Michelle Ricketts,Nilesh J. Samani,Stephen Sawcer,A. Strange,Richard C. Trembath,Ananth C. Viswanathan,Matthew Waller,Paul A. Weston,Pamela Whittaker,Sara Widaa,Nicholas W. Wood,Gil McVean,John D. Reveille,B P Wordsworth,Brown,Peter Donnelly +91 more
TL;DR: This paper reported the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P -8 in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9.
Journal ArticleDOI
NKG2D ligands: key targets of the immune response
Segundo Gonzalez,Alejandro López-Soto,Beatriz Suarez-Alvarez,Antonio López-Vázquez,Carlos López-Larrea +4 more
TL;DR: In this review, the recent advances in understanding the regulation of NKG2D ligand expression and their therapeutic implications are analyzed.