J
J. Tomfohrde
Researcher at University of Texas Southwestern Medical Center
Publications - 11
Citations - 2893
J. Tomfohrde is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Locus (genetics) & Genetic linkage. The author has an hindex of 10, co-authored 11 publications receiving 2832 citations. Previous affiliations of J. Tomfohrde include University of Texas Health Science Center at San Antonio & University of Texas System.
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Journal ArticleDOI
High resolution of human evolutionary trees with polymorphic microsatellites
Anne M. Bowcock,Andres Ruiz-Linares,J. Tomfohrde,Eric Minch,J.R. Kidd,Luigi Luca Cavalli-Sforza +5 more
TL;DR: It is shown that polymorphic microsatellites (primarily CA repeats) allow trees of human individuals to be constructed that reflect their geographic origin with remarkable accuracy by the analysis of a large number of loci for each individual, in spite of the small variations in allele frequencies existing between populations.
Journal ArticleDOI
Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q
J. Tomfohrde,Alan Silverman,Robert Barnes,Marcelo Fernandez-Vina,Melodie Young,Detra Lory,L. F. Morris,Kirk D. Wuepper,Peter Stastny,Alan Menter,Anne M. Bowcock +10 more
TL;DR: This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.
Journal Article
A gene for familial psoriasis susceptibility maps to the distal end of human chromosome 17q
TL;DR: In this paper, a gene for psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome wide linkage-analysis with polymorphic microsatellites and eight multiply affected psorsiasis kindreds.
Journal ArticleDOI
A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2
Ludwig Thierfelder,Calum A. MacRae,Hugh Watkins,J. Tomfohrde,Marshall V. Williams,William J. McKenna,K. Bohm,G. Noeske,M. Schlepper,Anne M. Bowcock +9 more
TL;DR: It is reported that a gene responsible for familial hypertrophic cardiomyopathy (FHC) in a kindred with a mild degree of cardiac hypertrophy maps to chromosome 15q2.
Journal ArticleDOI
A linkage map of human chromosome 15 with an average resolution of 2 cM and containing 55 polymorphic microsatellites
Jacques S. Beckmann,J. Tomfohrde,Robert Barnes,Williams M,O. Broux,Isabelle Richard,Jean Weissenbach,Anne M. Bowcock +7 more
TL;DR: A 2.0 centiMorgan (cM) resolution genetic linkage map for chromosome 15q that contains 55 polymorphic satellites and 3 RFLPs that have placed on the map with odds for order of at least 1,000:1 is constructed.