Journal ArticleDOI
High resolution of human evolutionary trees with polymorphic microsatellites
Anne M. Bowcock,Andres Ruiz-Linares,J. Tomfohrde,Eric Minch,J.R. Kidd,Luigi Luca Cavalli-Sforza +5 more
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TLDR
It is shown that polymorphic microsatellites (primarily CA repeats) allow trees of human individuals to be constructed that reflect their geographic origin with remarkable accuracy by the analysis of a large number of loci for each individual, in spite of the small variations in allele frequencies existing between populations.Abstract:
Genetic variation at hypervariable loci is being used extensively for linkage analysis and individual identification, and may be useful for inter-population studies. Here we show that polymorphic microsatellites (primarily CA repeats) allow trees of human individuals to be constructed that reflect their geographic origin with remarkable accuracy. This is achieved by the analysis of a large number of loci for each individual, in spite of the small variations in allele frequencies existing between populations. Reliable evolutionary relationships could also be established in comparisons among human populations but not among great ape species, probably because of constraints on allele length variation. Among human populations, diversity of microsatellites is highest in Africa, which is in contrast to other nuclear markers and supports the hypothesis of an African origin for humans.read more
Citations
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Inference of population structure using multilocus genotype data
TL;DR: Pritch et al. as discussed by the authors proposed a model-based clustering method for using multilocus genotype data to infer population structure and assign individuals to populations, which can be applied to most of the commonly used genetic markers, provided that they are not closely linked.
Journal ArticleDOI
Population structure and eigenanalysis
TL;DR: An approach to studying population structure (principal components analysis) is discussed that was first applied to genetic data by Cavalli-Sforza and colleagues, and results from modern statistics are used to develop formal significance tests for population differentiation.
Journal ArticleDOI
A measure of population subdivision based on microsatellite allele frequencies.
TL;DR: It was found that, under the generalized stepwise mutation model, R( ST) provides relatively unbiased estimates of migration rates and times of population divergence while F(ST) tends to show too much population similarity, particularly when migration rates are low or divergence times are long.
Journal ArticleDOI
Genetic Structure of Human Populations
Noah A. Rosenberg,Jonathan K. Pritchard,James L. Weber,Howard M. Cann,Kenneth K. Kidd,Lev A. Zhivotovsky,Marcus W. Feldman +6 more
TL;DR: General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies.
Journal ArticleDOI
The comparison of RFLP, RAPD, AFLP and SSR (microsatellite) markers for germplasm analysis
Wayne Powell,Michele Morgante,Chaz Andre,Michael K. Hanafey,Julie Vogel,Scott V. Tingey,Antoni Rafalski +6 more
TL;DR: A comparison of genetic similarity matrices revealed that, if the comparison involved both cultivated and wild soybean accessions, estimates based on RFLPs, RAPD, AFLPs and SSRs are highly correlated, indicating congruence between these assays.
References
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TL;DR: A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families.
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