C
Calum A. MacRae
Researcher at Brigham and Women's Hospital
Publications - 366
Citations - 25092
Calum A. MacRae is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Zebrafish & Medicine. The author has an hindex of 74, co-authored 323 publications receiving 22232 citations. Previous affiliations of Calum A. MacRae include Oregon Health & Science University & University College London.
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Journal ArticleDOI
Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease.
Diane Fatkin,Calum A. MacRae,Takeshi Sasaki,Matthew R. Wolff,Maurizio Porcu,Michael P. Frenneaux,John Atherton,Humberto Vidaillet,Serena Spudich,Umberto De Girolami,Jonathan G. Seidman,Francesco Muntoni,G. W. F. Muehle,Wendy Johnson,Barbara McDonough,Christine E. Seidman +15 more
TL;DR: Missense mutations in the rod domain of the lamin A/C gene provide a genetic cause for dilated cardiomyopathy and indicate that this intermediate filament protein has an important role in cardiac conduction and contractility.
Journal ArticleDOI
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
Sekar Kathiresan,Benjamin F. Voight,Shaun Purcell,Kiran Musunuru,Diego Ardissino,Pier Mannuccio Mannucci,Sonia S. Anand,James C. Engert,Nilesh J. Samani,Heribert Schunkert,Jeanette Erdmann,Muredach P. Reilly,Daniel J. Rader,Thomas M. Morgan,John A. Spertus,Monika Stoll,Domenico Girelli,Pascal P. McKeown,Christopher Patterson,David S. Siscovick,Christopher J. O'Donnell,Roberto Elosua,Leena Peltonen,Veikko Salomaa,Stephen M. Schwartz,Olle Melander,David Altshuler,Pier Angelica Merlini,Carlo Berzuini,Luisa Bernardinelli,Flora Peyvandi,Marco Tubaro,Patrizia Celli,Maurizio Ferrario,Raffaela Fetiveau,Nicola Marziliano,Giorgio Casari,Michele Galli,Flavio Ribichini,Marco Rossi,Francesco Bernardi,Pietro Zonzin,Alberto Piazza,Jean Yee,Yechiel Friedlander,Jaume Marrugat,Gavin Lucas,Isaac Subirana,Joan Sala,Rafael Ramos,James B. Meigs,Gordon H. Williams,David M. Nathan,Calum A. MacRae,Aki S. Havulinna,Göran Berglund,Joel N. Hirschhorn,Rosanna Asselta,Stefano Duga,Marta Spreafico,Mark J. Daly,James Nemesh,Joshua M. Korn,Steven A. McCarroll,Aarti Surti,Candace Guiducci,Lauren Gianniny,Daniel B. Mirel,Melissa Parkin,Noël P. Burtt,Stacey Gabriel,John R. Thompson,Peter S. Braund,Benjamin J. Wright,Anthony J. Balmforth,Stephen G. Ball,Alistair S. Hall,Patrick Linsel-Nitschke,Wolfgang Lieb,Andreas Ziegler,Inke R. König,Christian Hengstenberg,Marcus Fischer,Klaus Stark,Anika Grosshennig,Michael Preuss,H-Erich Wichmann,Stefan Schreiber,Willem H. Ouwehand,Panos Deloukas,Michael Scholz,François Cambien,Mingyao Li,Zhen Chen,Robert L. Wilensky,William H. Matthai,Atif Qasim,Hakon Hakonarson,Joe Devaney,Mary-Susan Burnett,Augusto D. Pichard,Kenneth M. Kent,Lowell F. Satler,Joseph M. Lindsay,Ron Waksman,Stephen E. Epstein,Thomas Scheffold,Klaus Berger,Andreas Huge,Nicola Martinelli,Oliviero Olivieri,Roberto Corrocher,Hilma Holm,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Kari Stefansson,Ron Do,Changchun Xie,David S. Siscovick +118 more
TL;DR: SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with my Cardiovascular Infarction risk.
Journal ArticleDOI
Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere.
Ludwig Thierfelder,Ludwig Thierfelder,Hugh Watkins,Hugh Watkins,Calum A. MacRae,Calum A. MacRae,Roger Lamas,William J. McKenna,Hans-Peter Vosberg,J.G. Seldman,Christine E. Seidman +10 more
TL;DR: It is shown that missense mutations in the alpha-tropomyosin gene cause familial hypertrophic cardiomyopathy (FHC), and it is suggested that abnormal stoichiometry of sarcomeric proteins can cause cardiac hypertrophy.
Journal ArticleDOI
Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes
Kazu Kikuchi,Jennifer E. Holdway,Andreas A. Werdich,Ryan M. Anderson,Yi Fang,Gregory F. Egnaczyk,Gregory F. Egnaczyk,Todd Evans,Calum A. MacRae,Didier Y.R. Stainier,Kenneth D. Poss +10 more
TL;DR: The results indicate that electrically coupled cardiac muscle regenerates after resection injury, primarily through activation and expansion of cardiomyocyte populations, which have implications for promoting regeneration of the injured human heart.
Journal ArticleDOI
Variants conferring risk of atrial fibrillation on chromosome 4q25
Daniel F. Gudbjartsson,David O. Arnar,Anna Helgadottir,Solveig Gretarsdottir,Hilma Holm,Asgeir Sigurdsson,Adalbjorg Jonasdottir,Adam Baker,Gudmar Thorleifsson,Kristleifur Kristjansson,Arnar Palsson,Thorarinn Blondal,Patrick Sulem,Valgerdur M Backman,Gudmundur A. Hardarson,Ebba Palsdottir,Agnar Helgason,Runa Sigurjonsdottir,Jon Th. Sverrisson,Konstantinos Kostulas,Maggie C.Y. Ng,Larry Baum,Wing-Yee So,Ka Sing Wong,Juliana C.N. Chan,Karen L. Furie,Steven M. Greenberg,Michelle Sale,Peter J. Kelly,Calum A. MacRae,Eric E. Smith,Jonathan Rosand,Jan Hillert,Ronald C.W. Ma,Patrick T. Ellinor,Gudmundur Thorgeirsson,Jeffrey R. Gulcher,Augustine Kong,Unnur Thorsteinsdottir,Kari Stefansson +39 more
TL;DR: A genome-wide association scan is performed, followed by replication studies in three populations of European descent and a Chinese population from Hong Kong and a strong association is found between two sequence variants on chromosome 4q25 and AF.