J
J. Ubbink
Publications - 3
Citations - 2426
J. Ubbink is an academic researcher. The author has contributed to research in topics: Homocysteine & Stroke. The author has an hindex of 3, co-authored 3 publications receiving 2315 citations.
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Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
Robert Clarke,Rory Collins,Sarah Lewington,Ann E. Donald,G. Alfthan,J. Tuomilehto,Egil Arnesen,Kaare H. Bønaa,Jacques Blacher,Godfried H.J. Boers,Andrew G. Bostom,M. L. Bots,D. E. Grobbee,Lars Brattström,Monique M.B. Breteler,A. Hofman,John C. Chambers,Jaspal S. Kooner,B. M. Coull,R. W. Evans,Lewis H. Kuller,S. Evers,Aaron R. Folsom,G. Freyburger,F. Parrot,J. Genest Jr,K. Dalery,I. M. Graham,Leslie Daly,Ellen K. Hoogeveen,Pieter J. Kostense,C.D.A. (Coen) Stehouwer,P. N. Hopkins,Paul F. Jacques,Jacob Selhub,F. C. Luft,P. Jungers,Arne Lindgren,Y. I. Lolin,F. Loehrer,Brian Fowler,Mohammad Azam Mansoor,M. R. Malinow,Pierre Ducimetière,Ottar Nygård,Helga Refsum,S. E. Vollset,Per Magne Ueland,G. S. Omenn,S. A. A. Beresford,J. M. Roseman,H. H. Parving,M. A. Gall,Ivan J. Perry,S Ebrahim,A. G. Shaper,Killian Robinson,D. W. Jacobsen,Steven M. Schwartz,David S. Siscovick,Meir J. Stampfer,C. H. Hennekens,Edith J. M. Feskens,Daan Kromhout,J. Ubbink,P. Elwood,J. Pickering,Petra Verhoef,A. Von Eckardstein,Helmut Schulte,Gerd Assmann,Nicholas J. Wald,M. R. Law,Peter H. Whincup,D. E. L. Wilcken,Paul Sherliker,P. Linksted,G Davey Smith +77 more
TL;DR: This meta-analysis of observational studies suggests that elevated homocysteine is at most a modest independent predictor of IHD and stroke risk in healthy populations.
Journal Article
Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials
Robert Clarke,Chris Frost,Paul Sherliker,Sarah Lewington,Rory Collins,Lars Brattström,Ingeborg A. Brouwer,M. van Dusseldorp,Rpm Steegers-Theunissen,Geraldine Cuskelly,Mark Ward,Helene McNulty,John D. Scott,M. den Heijer,Henk J. Blom,N.M.J. van der Put,CJ Shorah,Malinow,M McMahon,Jonathan A. Tobert,D Kush,E Joosten,R Riezier,Klaus Pietrzik,Jutta Dierkes,A Bronstrup,Paul F. Jacques,Joel B. Mason,Irwin H. Rosenberg,J Thambyrajah,Martin J Landray,Jonathan N. Townend,David C. Wheeler,J. Ubbink,F.V.A. van Oort,Alida Melse-Boonstra,Petra Verhoef,Jayne V. Woodside,J. W. G. Yarnell,Ian S. Young,Alun Evans,David S. Wald,Malcolm Law,Nicholas J. Wald +43 more
TL;DR: The objectives were to ascertain the lowest dose of folic acid associated with the maximum reduction in homocysteine concentrations and to determine the additional relevance of vitamins B-12 and B-6.
Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis JAMA 2002 288 2015 2022 12387654
Robert Clarke,Rory Collins,Sarah Lewington,Ann E. Donald,G. Alfthan,J. Tuomilehto,Egil Arnesen,Kaare H. Bønaa,Jacques Blacher,Godfried H.J. Boers,Andrew G. Bostom,M. L. Bots,D. E. Grobbee,Lars Brattström,Monique M.B. Breteler,A. Hofman,John C. Chambers,Jaspal S. Kooner,B. M. Coull,R. W. Evans,Lewis H. Kuller,S. Evers,Aaron R. Folsom,G. Freyburger,F. Parrot,J. Genest Jr,K. Dalery,I. M. Graham,Leslie Daly,Ellen K. Hoogeveen,Pieter J. Kostense,C.D.A. (Coen) Stehouwer,P. N. Hopkins,Paul F. Jacques,Jacob Selhub,F. C. Luft,P. Jungers,Arne Lindgren,Y. I. Lolin,F. Loehrer,Brian Fowler,Mohammad Azam Mansoor,M. R. Malinow,Pierre Ducimetière,Ottar Nygård,Helga Refsum,S. E. Vollset,Per Magne Ueland,G. S. Omenn,S. A. A. Beresford,J. M. Roseman,H. H. Parving,M. A. Gall,Ivan J. Perry,S Ebrahim,A. G. Shaper,Killian Robinson,D. W. Jacobsen,Steven M. Schwartz,David S. Siscovick,Meir J. Stampfer,C. H. Hennekens,Edith J. M. Feskens,Daan Kromhout,J. Ubbink,P. Elwood,J. Pickering,Petra Verhoef,A. Von Eckardstein,Helmut Schulte,Gerd Assmann,Nicholas J. Wald,M. R. Law,Peter H. Whincup,D. E. L. Wilcken,Paul Sherliker,P. Linksted,G. D. Smith +77 more
TL;DR: In this article, a meta-analysis of observational studies suggests that elevated homocysteine is at most a modest independent predictor of IHD and stroke risk in healthy populations, with a 25% lower usual (corrected for regression dilution bias) homocyteine level (about 3 micromol/L [0.41 mg/L]) was associated with an 11% (OR, 0.89; 95% confidence interval [CI], 0.83-0.96) lower IHD risk and 19%(OR,0.81, 95%