L
Lars Brattström
Researcher at Lund University
Publications - 45
Citations - 11612
Lars Brattström is an academic researcher from Lund University. The author has contributed to research in topics: Homocysteine & Risk factor. The author has an hindex of 34, co-authored 45 publications receiving 11362 citations. Previous affiliations of Lars Brattström include Linköping University.
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Journal ArticleDOI
Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
Robert Clarke,Rory Collins,Sarah Lewington,Ann E. Donald,G. Alfthan,J. Tuomilehto,Egil Arnesen,Kaare H. Bønaa,Jacques Blacher,Godfried H.J. Boers,Andrew G. Bostom,M. L. Bots,D. E. Grobbee,Lars Brattström,Monique M.B. Breteler,A. Hofman,John C. Chambers,Jaspal S. Kooner,B. M. Coull,R. W. Evans,Lewis H. Kuller,S. Evers,Aaron R. Folsom,G. Freyburger,F. Parrot,J. Genest Jr,K. Dalery,I. M. Graham,Leslie Daly,Ellen K. Hoogeveen,Pieter J. Kostense,C.D.A. (Coen) Stehouwer,P. N. Hopkins,Paul F. Jacques,Jacob Selhub,F. C. Luft,P. Jungers,Arne Lindgren,Y. I. Lolin,F. Loehrer,Brian Fowler,Mohammad Azam Mansoor,M. R. Malinow,Pierre Ducimetière,Ottar Nygård,Helga Refsum,S. E. Vollset,Per Magne Ueland,G. S. Omenn,S. A. A. Beresford,J. M. Roseman,H. H. Parving,M. A. Gall,Ivan J. Perry,S Ebrahim,A. G. Shaper,Killian Robinson,D. W. Jacobsen,Steven M. Schwartz,David S. Siscovick,Meir J. Stampfer,C. H. Hennekens,Edith J. M. Feskens,Daan Kromhout,J. Ubbink,P. Elwood,J. Pickering,Petra Verhoef,A. Von Eckardstein,Helmut Schulte,Gerd Assmann,Nicholas J. Wald,M. R. Law,Peter H. Whincup,D. E. L. Wilcken,Paul Sherliker,P. Linksted,G Davey Smith +77 more
TL;DR: This meta-analysis of observational studies suggests that elevated homocysteine is at most a modest independent predictor of IHD and stroke risk in healthy populations.
Journal ArticleDOI
Plasma homocysteine as a risk factor for vascular disease: The European Concerted Action Project.
Graham Im,Leslie Daly,Helga Refsum,Killian Robinson,Lars Brattström,Per Magne Ueland,Roberto Palma-Reis,Godfried H.J. Boers,Richard G. Sheahan,Israelsson B,Cuno S.P.M. Uiterwaal,Raymond Meleady,Dorothy McMaster,Petra Verhoef,Jacqueline C.M. Witteman,Paolo Rubba,Bellet H,Jan C. Wautrecht,de Valk Hw,Sales Lúis Ac,Parrot-Rouland Fm,K.S. Tan,I.M. Higgins,Danielle Garcon,Generoso Andria +24 more
TL;DR: An increased plasma total homocysteine level confers an independent risk of vascular disease similar to that of smoking or hyperlipidemia, and compared with nonusers of vitamin supplements, the small number of subjects taking such vitamins appeared to have a substantially lower risk ofascular disease, a proportion of which was attributable to lower plasma homocy steine levels.
Journal ArticleDOI
Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomised trials
Lars Brattström,M. den Heijer,Henk J. Blom,Gerard M. J. Bos,A. P. Spaans,F. R. Rosendaal,Chris M.G. Thomas,H.L. Haak +7 more
TL;DR: Higher blood homocysteine concentrations seem to be associated with higher risks of occlusive vascular disease and with lower blood concentrations of folate and vitamins B-12 and B-6 Large scale randomised trials of such regimens in people at high risk are now needed to determine whether lowering bloodhomocysteined concentrations reduces the risk of vascular disease.
Journal ArticleDOI
Common Methylenetetrahydrofolate Reductase Gene Mutation Leads to Hyperhomocysteinemia but Not to Vascular Disease The Result of a Meta-Analysis
TL;DR: The findings suggest that the mild hyperhomocysteinemia found frequently in vascular disease patients is not causally related to the pathogenesis of the vascular disease.
Journal ArticleDOI
Low Circulating Folate and Vitamin B6 Concentrations Risk Factors for Stroke, Peripheral Vascular Disease, and Coronary Artery Disease
Killian Robinson,Kristopher L. Arheart,Helga Refsum,Lars Brattström,Godfried H.J. Boers,Per Magne Ueland,Paolo Rubba,Roberto Palma-Reis,Raymond Meleady,Leslie Daly,Jacqueline C.M. Witteman,Ian D. Graham +11 more
TL;DR: In this paper, the authors explored the interrelationships between homocysteine, B vitamins, and vascular diseases and evaluated the role of these vitamins as risk factors for atherosclerosis.