J
J. W. G. Yarnell
Researcher at Queen's University Belfast
Publications - 42
Citations - 2739
J. W. G. Yarnell is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Risk factor & Population. The author has an hindex of 23, co-authored 42 publications receiving 2657 citations.
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Journal Article
Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials
Robert Clarke,Chris Frost,Paul Sherliker,Sarah Lewington,Rory Collins,Lars Brattström,Ingeborg A. Brouwer,M. van Dusseldorp,Rpm Steegers-Theunissen,Geraldine Cuskelly,Mark Ward,Helene McNulty,John D. Scott,M. den Heijer,Henk J. Blom,N.M.J. van der Put,CJ Shorah,Malinow,M McMahon,Jonathan A. Tobert,D Kush,E Joosten,R Riezier,Klaus Pietrzik,Jutta Dierkes,A Bronstrup,Paul F. Jacques,Joel B. Mason,Irwin H. Rosenberg,J Thambyrajah,Martin J Landray,Jonathan N. Townend,David C. Wheeler,J. Ubbink,F.V.A. van Oort,Alida Melse-Boonstra,Petra Verhoef,Jayne V. Woodside,J. W. G. Yarnell,Ian S. Young,Alun Evans,David S. Wald,Malcolm Law,Nicholas J. Wald +43 more
TL;DR: The objectives were to ascertain the lowest dose of folic acid associated with the maximum reduction in homocysteine concentrations and to determine the additional relevance of vitamins B-12 and B-6.
Journal ArticleDOI
The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia
Dawn L. Harmon,Jayne V. Woodside,J. W. G. Yarnell,D. McMaster,Ian S. Young,E.E. McCrum,K.F. Gey,Alexander S. Whitehead,Alun Evans +8 more
TL;DR: The MTHFR thermolabile genotype should be considered when population studies are designed to determine the effective homocysteine-lowering dose of dietary folate supplements, and when prophylactic doses of folate are recommended for individuals.
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Are the Framingham and PROCAM coronary heart disease risk functions applicable to different European populations? The PRIME Study.
J.P Empana,Pierre Ducimetière,Dominique Arveiler,Jean Ferrières,Alun Evans,Jean-Bernard Ruidavets,Bernadette Haas,J. W. G. Yarnell,Annie Bingham,Philippe Amouyel,Jean Dallongeville +10 more
TL;DR: The Framingham and PROCAM risk functions should not be used to estimate the absolute CHD risk of middle-aged men in Belfast and France without any CHD history because of a clear overestimation.
Journal ArticleDOI
Leg length, insulin resistance, and coronary heart disease risk: The Caerphilly Study
G Davey Smith,Rosemary Greenwood,David Gunnell,Peter M. Sweetnam,J. W. G. Yarnell,Peter Creighton Elwood +5 more
TL;DR: Leg length is the component of stature related to insulin resistance and coronary heart disease risk and the reported associations suggest that pre-adult influences are important in the aetiology of coronaryHeart disease and insulin resistance.
Journal ArticleDOI
Associations of the HDL2 and HDL3 cholesterol subfractions with the development of ischemic heart disease in British men. The Caerphilly and Speedwell Collaborative Heart Disease Studies.
P. M. Sweetnam,C. H. Bolton,J. W. G. Yarnell,D. Bainton,I. A. Baker,Peter Creighton Elwood,N. E. Miller +6 more
TL;DR: In British men, both HDL2 and HDL3 cholesterol are inversely associated with the incidence of ischemic heart disease, and the prediction of the risk of IHD from total HDL cholesterol alone could not be improved upon by measurement of the two HDL subfractions.