J
J. van der Vlag
Researcher at Radboud University Nijmegen
Publications - 47
Citations - 1663
J. van der Vlag is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 19, co-authored 31 publications receiving 1512 citations. Previous affiliations of J. van der Vlag include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Apoptosis in the pathogenesis of systemic lupus erythematosus
Luis E. Muñoz,C.C.A.W. van Bavel,Sandra Franz,Jo H. M. Berden,Martin Herrmann,J. van der Vlag +5 more
TL;DR: Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease resulting from autoimmune responses against nuclear autoantigens, and apoptosis and clearance of apoptotic cells/material are considered key processes in the aetiology of SLE.
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Transmission of modified nucleosomes from the mouse male germline to the zygote and subsequent remodeling of paternal chromatin.
G.W. van der Heijden,Alwin A.H.A. Derijck,Liliana Ramos,Maud Giele,J. van der Vlag,P. de Boer +5 more
TL;DR: It is shown that sperm constitutive heterochromatin is enriched for nucleosomes carrying specific histone modifications which are transmitted to the zygote, which suggests an epigenetic mechanism for inheritance of chromosomal architecture.
Journal Article
Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis. Commentary
C.C.A.W. van Bavel,J. van der Vlag,Jhm Berden,Manar Kalaaji,Kristin A. Fenton,Elin Synnøve Mortensen,Randi Olsen,Gunnar Sturfelt,Per Alm,Ole Petter Rekvig +9 more
TL;DR: In this article, the authors analyzed renal tissue from anti-dsDNA antibody-positive lupus patients with nephritis by morphological and immunological assays, including immune electron microscopy (IEM) and colocalization IEM, an EM-based confocal microscopy assay.
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Increased expression of heparanase in overt diabetic nephropathy
M.J.W. van den Hoven,Angelique L.W.M.M. Rops,Marinka A.H. Bakker,Jan Aten,N. Rutjes,Peggy Roestenberg,Roel Goldschmeding,Eyal Zcharia,Israel Vlodavsky,J. van der Vlag,Jo H. M. Berden +10 more
TL;DR: The observations suggest that HPSE is involved in the pathogenesis of proteinuria in overt DNP by degradation of HS, which is upregulated in rats and mice with STZ-induced diabetes.
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The role of reactive oxygen species in apoptosis of the diabetic kidney
TL;DR: Some mechanisms of apoptosis are discussed and several strategies that have been probed to ameliorate, or to prevent apoptosis in the diabetic kidney are discussed.