J
Jhm Berden
Researcher at Radboud University Nijmegen
Publications - 75
Citations - 3932
Jhm Berden is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Glomerular basement membrane & Heparan sulfate. The author has an hindex of 35, co-authored 75 publications receiving 3852 citations.
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Journal ArticleDOI
Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo.
C. Kramers,Machteld N. Hylkema,M. C. J. Van Bruggen,R. Van De Lagemaat,H.B.P.M. Dijkman,K.J.M. Assmann,R.J.T. Smeenk,Jhm Berden +7 more
TL;DR: It is concluded that anti-nucleosome mAbs, which do not bind DNA, become DNA reactive once complexed to nucleosomal antigens, and these complexed mAbs can bind to the GBM.
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A monoclonal antibody against GBM heparan sulfate induces an acute selective proteinuria in rats
J. van den Born,L.P.W.J. van den Heuvel,M. A. H. Bakker,J.H. Veerkamp,K.J.M. Assmann,Jhm Berden +5 more
TL;DR: After immunization of mice with partially-purified heparan sulfate proteoglycan (HSPG) isolated from rat glomeruli, a monoclonal antibody (mAb JM-403) was obtained, which was directed against heparin sulfate (HS), the glycosaminoglycan side chain of HSPG.
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Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial
Cecile Grootscholten,Gerry Ligtenberg,E.C. Hagen,A.W.L. van den Wall Bake,J.W. de Glas-Vos,Marc Bijl,Karel J.M. Assmann,Jan A. Bruijn,J.J. Weening,H.C. van Houwelingen,Ronald H. W. M. Derksen,Jhm Berden +11 more
TL;DR: In this open-label randomized controlled trial, cyclophosphamide was superior to azathioprine with regard to renal relapses and HZV and Parameters for ovarian function did not differ between the two groups.
Journal ArticleDOI
Glomerular heparan sulfate alterations: mechanisms and relevance for proteinuria.
TL;DR: Evidence was obtained that hyperglycemia led to a down-regulation of HS synthesis, accompanied by a reduction in the degree of HS sulfation, as well as in streptozotocin-induced diabetic nephropathy and during culture of glomerular cells under high glucose conditions.
Journal ArticleDOI
Expression of glomerular extracellular matrix components in human diabetic nephropathy: decrease of heparan sulphate in the glomerular basement membrane
Jouke T. Tamsma,J. van den Born,J. A. Bruijn,K.J.M. Assmann,Jan J. Weening,Jan J. Weening,Jhm Berden,Jörgen Wieslander,E. Schrama,J. Hermans,J.H. Veerkamp +10 more
TL;DR: The decreased HS staining in the GBM may reflect the potentially disrupted charge barrier in diabetic nephropathy and be a sign of a functional relationship.