J
J.Y. Zou
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 1
Citations - 138
J.Y. Zou is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Hydrogen bond & Glycosidic bond. The author has an hindex of 1, co-authored 1 publications receiving 130 citations.
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The active site of cellobiohydrolase Cel6A from Trichoderma reesei: the roles of aspartic acids D221 and D175.
Anu Koivula,Laura Ruohonen,Gerd Wohlfahrt,Tapani Reinikainen,Tuula T. Teeri,K. Piens,M. Claeyssens,M. Weber,A. Vasella,D. Becker,M.L. Sinnott,J.Y. Zou,Gerard J. Kleywegt,M. Szardenings,Jerry Ståhlberg,T.A. Jones +15 more
TL;DR: Site-directed mutagenesis, X-ray crystallography, and enzyme kinetic studies have been used to confirm the role of residue D221 as the catalytic acid in Cel6A, and suggest that the single-displacement mechanism of Cel 6A may not directly involve a catalytic base.