J
J. Zguricas
Researcher at Erasmus University Rotterdam
Publications - 9
Citations - 352
J. Zguricas is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Polydactyly & Triphalangeal thumb. The author has an hindex of 6, co-authored 9 publications receiving 345 citations.
Papers
More filters
Journal ArticleDOI
The gene for triphalangeal thumb maps to the subtelomeric region of chromosome 7q
Peter Heutink,J. Zguricas,van Oosterhout L,Guido J. Breedveld,Leon Testers,Lodewijk A. Sandkuijl,P.J.L.M. Snijders,Weissenbach J,Dick Lindhout,Steven E.R. Hovius +9 more
TL;DR: To the authors' knowledge this is the first time that a human gene involved solely in the pathologic morphogenesis of the hand and feet has been localized.
Journal ArticleDOI
Clinical and genetic studies on 12 preaxial polydactyly families and refinement of the localisation of the gene responsible to a 1.9 cM region on chromosome 7q36
J. Zguricas,Henk C. Heus,Estela Morales-Peralta,Guido J. Breedveld,Bertus Kuyt,Ethem F Mumcu,Wendela F. Bakker,Nurten Akarsu,Simon P J Kay,Steven E.R. Hovius,Luis Heredero-Baute,Ben A. Oostra,Peter Heutink +12 more
TL;DR: Combining the results with other studies suggests that all non-syndromic preaxial polydactylies associated with triphalangism of the thumb are caused by a single genetic locus, but that there is genetic heterogeneity forPreaxialpolydactyly associated with duplications of biphalangeal thumbs.
Journal ArticleDOI
A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36.
Henk C. Heus,Anne Hing,Marijke J. van Baren,Marijke Joosse,Guido J. Breedveld,J. C. Wang,Andrea K. Burgess,Helen Donnis-Keller,Cathleen Berglund,J. Zguricas,Stephen W. Scherer,Johanna M. Rommens,Ben A. Oostra,Peter Heutink +13 more
TL;DR: A detailed physical map of the preaxial polydactyly candidate region is constructed and the homeobox gene HLXB9, a putative receptor C7orf2, and two transcripts of unknown function map in the refined candidate region.
Journal ArticleDOI
Genetics of limb development and congenital hand malformations
TL;DR: An overview of the genetic factors involved in limb development, followed by summarized discoveries in the genetics of human congenital hand malformations are presented.
Journal ArticleDOI
Phenotypic analysis of triphalangeal thumb and associated hand malformations.
TL;DR: Four white Dutch families in which triphalangeal thumb has variable expression are described, and the potential significance of linkage and molecular genetic analysis for better insight into the pathogenesis of complex hand malformations is discussed.