J
Jaana Lahti-Domenici
Researcher at Harvard University
Publications - 15
Citations - 2993
Jaana Lahti-Domenici is an academic researcher from Harvard University. The author has contributed to research in topics: Breast cancer & DNA methylation. The author has an hindex of 14, co-authored 14 publications receiving 2850 citations. Previous affiliations of Jaana Lahti-Domenici include Oulu University Hospital.
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Journal ArticleDOI
Molecular characterization of the tumor microenvironment in breast cancer
Minna Allinen,Rameen Beroukhim,Li Cai,Cameron Brennan,Jaana Lahti-Domenici,Haiyan Huang,Haiyan Huang,Dale Porter,Min Hu,Lynda Chin,Andrea L. Richardson,Stuart J. Schnitt,William R. Sellers,William R. Sellers,Kornelia Polyak +14 more
TL;DR: Despite the dramatic gene expression changes in all cell types, genetic alterations were detected only in cancer epithelial cells and chemokines may play a role in breast tumorigenesis by acting as paracrine factors.
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Converting a breast cancer microarray signature into a high-throughput diagnostic test.
Annuska M. Glas,Arno Floore,Leonie J. M. J. Delahaye,Anke T. Witteveen,Rob Pover,Niels Bakx,Jaana Lahti-Domenici,Tako J. Bruinsma,Marc O. Warmoes,René Bernards,Lodewyk F. A. Wessels,Laura J. van't Veer +11 more
TL;DR: This report demonstrates for the first time that microarray technology can be used as a reliable diagnostic tool and is therefore an excellent tool to predict outcome of disease in breast cancer patients.
Journal Article
Molecular Markers in Ductal Carcinoma in Situ of the Breast
Dale Porter,Jaana Lahti-Domenici,Aparna Keshaviah,Young Kyung Bae,Pedram Argani,Jeffrey R. Marks,Andrea L. Richardson,Amiel Cooper,Robert L. Strausberg,Gregory J. Riggins,Stuart J. Schnitt,Edward Gabrielson,Rebecca Gelman,Kornelia Polyak +13 more
TL;DR: It is found that that the most dramatic transcriptome change occurs at the normal to DCIS transition, while there is no clear universal "in situ" or "invasive" tumor molecular signature.
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Gene Expression Profiling to Identify the Histogenetic Origin of Metastatic Adenocarcinomas of Unknown Primary
Hugo M. Horlings,Ryan van Laar,Jan-Martijn Kerst,Helgi H. Helgason,Jelle Wesseling,Jacobus J.M. van der Hoeven,Marc O. Warmoes,Arno Floore,Anke T. Witteveen,Jaana Lahti-Domenici,Annuska M. Glas,Laura J. van't Veer,Daphne de Jong +12 more
TL;DR: The gene expression platform can classify correctly from FFPE samples the majority of tumors classes both in patients with known primary and in patientsWith ACUP, and represents an additional analytic approach to assist with the histogenetic diagnosis of patients with ACUP.
Journal ArticleDOI
Very High Frequency of Hypermethylated Genes in Breast Cancer Metastasis to the Bone, Brain, and Lung
Jyoti Mehrotra,Mustafa Vali,Megan McVeigh,Scott L. Kominsky,Mary Jo Fackler,Jaana Lahti-Domenici,Kornelia Polyak,Nicoletta Sacchi,Elizabeth Garrett-Mayer,Pedram Argani,Saraswati Sukumar +10 more
TL;DR: The frequent presence of hypermethylated genes in locoregional and distant metastasis could render them particularly susceptible to therapy targeted toward gene reactivation combining demethylating agents, histone deacetylase inhibitors, and/or differentiating agents.