A
Arno Floore
Researcher at Netherlands Cancer Institute
Publications - 40
Citations - 4093
Arno Floore is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 21, co-authored 39 publications receiving 3857 citations.
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Journal ArticleDOI
Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer
Marc Buyse,Sherene Loi,Laura J. van't Veer,Giuseppe Viale,Mauro Delorenzi,Annuska M. Glas,Mahasti Saghatchian d'Assignies,Jonas Bergh,Rosette Lidereau,Paul Ellis,Adrian L. Harris,Jan Bogaerts,Patrick Therasse,Arno Floore,Mohamed Amakrane,Fanny Piette,Emiel J. Th. Rutgers,Christos Sotiriou,Fatima Cardoso,Martine Piccart +19 more
TL;DR: The 70-gene signature adds independent prognostic information to clinicopathologic risk assessment for patients with early breast cancer and outperformed the clinicopathological risk assessment in predicting all endpoints.
Journal ArticleDOI
Converting a breast cancer microarray signature into a high-throughput diagnostic test.
Annuska M. Glas,Arno Floore,Leonie J. M. J. Delahaye,Anke T. Witteveen,Rob Pover,Niels Bakx,Jaana Lahti-Domenici,Tako J. Bruinsma,Marc O. Warmoes,René Bernards,Lodewyk F. A. Wessels,Laura J. van't Veer +11 more
TL;DR: This report demonstrates for the first time that microarray technology can be used as a reliable diagnostic tool and is therefore an excellent tool to predict outcome of disease in breast cancer patients.
Journal ArticleDOI
The 70-gene prognosis-signature predicts disease outcome in breast cancer patients with 1-3 positive lymph nodes in an independent validation study.
S. Mook,Marjanka K. Schmidt,Giuseppe Viale,Giuseppe Viale,Giancarlo Pruneri,Giancarlo Pruneri,Inge Eekhout,Arno Floore,Annuska M. Glas,Jan Bogaerts,Fatima Cardoso,Martine Piccart-Gebhart,Emiel J. Th. Rutgers,Laura J. van't Veer +13 more
TL;DR: The 70-gene prognosis-signature outperforms traditional prognostic factors in predicting disease outcome in patients with 1–3 positive nodes and may be safely spared adjuvant chemotherapy in node-positive breast cancer.
Journal ArticleDOI
Tamoxifen resistance by a conformational arrest of the estrogen receptor α after PKA activation in breast cancer
Rob Michalides,Alexander Griekspoor,Astrid Balkenende,Desiree Verwoerd,Lennert Janssen,Kees Jalink,Arno Floore,Arno Velds,Laura van 't Veer,Jacques Neefjes +9 more
TL;DR: It is shown that phosphorylation of serine-305 in the hinge region of ERalpha by protein kinase A (PKA) induced resistance to tamoxifen, which induces a switch from antagonistic to agonistic effects of tamoxIFen on ERalpha.
Journal ArticleDOI
Use of 70-gene signature to predict prognosis of patients with node-negative breast cancer: a prospective community-based feasibility study (RASTER)
Jolien M. Bueno-de-Mesquita,Wim H. van Harten,Valesca P. Retèl,Laura J. van't Veer,Frits S.A.M. van Dam,Kim Karsenberg,Kirsten F. L. Douma,Harm van Tinteren,Johannes L. Peterse,Jelle Wesseling,Tin S. Wu,Douwe Atsma,Emiel J. Th. Rutgers,Guido Brink,Arno Floore,Annuska M. Glas,Rudi M. H. Roumen,Frank E. Bellot,Cees van Krimpen,Sjoerd Rodenhuis,Marc J. van de Vijver,Sabine C. Linn +21 more
TL;DR: The feasibility of implementation of the 70-gene prognosis signature in community-based settings and its effect on adjuvant systemic treatment decisions when considered with treatment advice formulated from the Dutch Institute for Healthcare Improvement (CBO) and other guidelines are assessed.