Jack H. Freed

TL;DR: In this article, it was shown that the commonly used models for analyzing ESR spectra from spin-labeled proteins or DNA systems are special cases of the more general slowly relaxing local structure (SRLS) model, wherein the nitroxide spin probe is taken as reorienting in a restricted local environment, which itself is relaxing on a longer time scale.

TL;DR: In this paper, it was shown that the changes in splittings arise entirely from a redistribution of the pi-electron spin density, and that the spin density is affected only by localized complexes between the solvent and polar substituents or heteroatoms in the radical.

TL;DR: In this paper, the authors extended the theory of ESR linewidths for dilute solutions of free radicals developed by Freed and Fraenkel to cover the possibility that the rotational motions of the free radicals are anisotropic.

TL;DR: The maximum entropy regularization method (MEM) is regarded as a complement to TikR by securing a positive pair distance distribution and enhancing the accuracy of TIKR.

TL;DR: It is shown that GltPh bearing two mutations introduced to impart characteristics of the human transporter exhibits markedly increased transport domain dynamics, which parallels an increased rate of substrate transport, thereby establishing a direct temporal relationship between transport domain motion and substrate uptake.