D
Daniel S. Terry
Researcher at St. Jude Children's Research Hospital
Publications - 49
Citations - 3977
Daniel S. Terry is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Förster resonance energy transfer & Allosteric regulation. The author has an hindex of 23, co-authored 45 publications receiving 3141 citations. Previous affiliations of Daniel S. Terry include Cornell University & Electronics and Telecommunications Research Institute.
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Journal ArticleDOI
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env
Young Do Kwon,Marie Pancera,Priyamvada Acharya,Ivelin S. Georgiev,Emma T. Crooks,Jason Gorman,M. Gordon Joyce,Miklos Guttman,Xiaochu Ma,Sandeep Narpala,Cinque Soto,Daniel S. Terry,Yongping Yang,Tongqing Zhou,Goran Ahlsen,Robert T. Bailer,Michael Chambers,Gwo-Yu Chuang,Nicole A. Doria-Rose,Aliaksandr Druz,Mark A. Hallen,Adam Harned,Tatsiana Kirys,Mark K. Louder,Sijy O'Dell,Gilad Ofek,Keiko Osawa,Madhu Prabhakaran,Mallika Sastry,Guillaume Stewart-Jones,Jonathan Stuckey,Paul V. Thomas,Tishina Tittley,Constance Williams,Baoshan Zhang,Hong Zhao,Zhou Zhou,Bruce R. Donald,Lawrence K. Lee,Susan Zolla-Pazner,Ulrich Baxa,Arne Schön,Ernesto Freire,Lawrence Shapiro,Kelly K. Lee,James Arthos,James B. Munro,Scott C. Blanchard,Walther Mothes,James M. Binley,Adrian B. McDermott,John R. Mascola,Peter D. Kwong +52 more
TL;DR: Antigenicity-guided structural design can be used both to delineate mechanism and to fix conformation, with DS-Env trimers in virus-like-particle and soluble formats providing a new generation of vaccine antigens.
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Substrate-modulated gating dynamics in a Na + -coupled neurotransmitter transporter homologue
Yongfang Zhao,Daniel S. Terry,Lei Shi,Matthias Quick,Harel Weinstein,Scott C. Blanchard,Jonathan A. Javitch +6 more
TL;DR: Substrate binding in this S2 site appears to act cooperatively with the primary substrate (S1) binding site to control intracellular gating more than 30 Å away, in a manner that allows the Na+ gradient to power the transport mechanism.
Journal ArticleDOI
Cyanine fluorophore derivatives with enhanced photostability
Roger B. Altman,Daniel S. Terry,Zhou Zhou,Qinsi Zheng,Peter Geggier,Rachel A. Kolster,Yongfang Zhao,Jonathan A. Javitch,J. David Warren,Scott C. Blanchard +9 more
TL;DR: It is demonstrated that the direct or proximal conjugation of cyclooctatetraene, 4-nitrobenzyl alcohol or Trolox to the cyanine fluorophore Cy5 dramatically enhanced fluorophores photostability without otherwise affecting its native spectral characteristics.
Journal ArticleDOI
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
Yongfang Zhao,Daniel S. Terry,Lei Shi,Harel Weinstein,Scott C. Blanchard,Jonathan A. Javitch +5 more
TL;DR: The direct observations of single-molecule transitions, reflecting structural dynamics of the intracellular region of the transporter that might be masked by ensemble averaging or suppressed under crystallographic conditions, are interpreted in the context of an allosteric mechanism that couples ion and substrate binding to transport.
Journal ArticleDOI
Single-molecule analysis of ligand efficacy in β2AR–G-protein activation
G. Glenn Gregorio,Matthieu Masureel,Daniel Hilger,Daniel S. Terry,Manuel F. Juette,Hong Zhao,Zhou Zhou,Jose Manuel Perez-Aguilar,Maria Hauge,Signe Mathiasen,Jonathan A. Javitch,Harel Weinstein,Brian K. Kobilka,Scott C. Blanchard +13 more
TL;DR: It is shown that partial and full agonists differentially affect TM6 motions to regulate the rate at which GDP-bound β2AR–Gs complexes are formed and the efficiency of nucleotide exchange leading to Gs activation, which sheds new light on the G-protein activation mechanism.