J
Jacob J. Bertrand
Researcher at University of California, San Francisco
Publications - 4
Citations - 807
Jacob J. Bertrand is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Pilus & Fimbria. The author has an hindex of 4, co-authored 4 publications receiving 719 citations.
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Journal ArticleDOI
Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms.
Kim Bundvig Barken,Sünje Johanna Pamp,Liang Yang,Morten Gjermansen,Jacob J. Bertrand,Mikkel Klausen,Michael Givskov,Cynthia B. Whitchurch,Joanne N. Engel,Tim Tolker-Nielsen +9 more
TL;DR: Evidence is presented that type IV pili, flagellum-mediated motility and quorum sensing-controlled DNA release are involved in the formation of mature multicellular structures in P. aeruginosa biofilms.
Journal ArticleDOI
Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa
Cynthia B. Whitchurch,Andrew J. Leech,Michael D. Young,Derek Kennedy,Derek Kennedy,Jennifer L Sargent,Jacob J. Bertrand,A Semmler,Albert S. Mellick,Paul R. Martin,Richard A. Alm,Matthew Hobbs,Scott A. Beatson,Bixing Huang,Lam Nguyen,James C. Commolli,Joanne N. Engel,Aldis Darzins,John S. Mattick +18 more
TL;DR: It is shown that the Chp chemosensory system controls twitching motility and type IV pili biogenesis through control of pili assembly and/or retraction as well as expression of the pilin subunit gene pilA, required for full virulence in a mouse model of acute pneumonia.
Journal ArticleDOI
Genetic Analysis of the Regulation of Type IV Pilus Function by the Chp Chemosensory System of Pseudomonas aeruginosa
TL;DR: It is demonstrated that the histidine kinase domain of ChpA and the phosphoacceptor sites of both PilG and PilH are required for type IV pilus function, suggesting that they form a phosphorelay system important in the regulation of pilus extension and retraction.
Journal ArticleDOI
Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways.
Cynthia B. Whitchurch,Scott A. Beatson,James C. Comolli,Thania Jakobsen,Jennifer L Sargent,Jacob J. Bertrand,Joyce T. West,Mikkel Klausen,Leslie L. Waite,Pil Jung Kang,Tim Tolker-Nielsen,John S. Mattick,Joanne N. Engel +12 more
TL;DR: The studies indicate that Vfr and FimL are components of intersecting pathways that control twitching motility, TTSS and autolysis in P. aeruginosa and suggest that the site(s) of spontaneous mutation is in a gene which lies upstream of vfr transcription, cAMP, production, and PQS synthesis.