J
Jacqueline K. Barton
Researcher at California Institute of Technology
Publications - 430
Citations - 45235
Jacqueline K. Barton is an academic researcher from California Institute of Technology. The author has contributed to research in topics: DNA & Base pair. The author has an hindex of 100, co-authored 429 publications receiving 43349 citations. Previous affiliations of Jacqueline K. Barton include City University of New York & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Sequence Dependence of Charge Transport through DNA Domains
TL;DR: The entire sequence within the DNA assembly is seen to govern CPC oxidation, not simply the bases intervening between CPC and the tethered photooxidant, and the mechanistic model for DNA charge transport is distinguished from polaron models.
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Electrochemistry using self-assembled DNA monolayers on highly oriented pyrolytic graphite.
TL;DR: The application of DNA-modified HOPG as a convenient and reproducible surface for electrochemical DNA sensors using DNA-mediated charge transport and the electrochemistry of previously inaccessible metallointercalators, Ru(bpy)2dppz2+ and Os(phen) 2dppZ2+, at the DNA- modified HopG surface are supported.
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Charge transport in DNA duplex/quadruplex conjugates.
TL;DR: The data indicate, furthermore, that in the conjugates examined, the guanine quadruplex provides a more effective trap than a 5'-GG-3'guanine doublet within duplex DNA, which requires consideration with respect to the analysis of oxidative DNA damage within the cell.
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Synthesis and characterization of iridium(III) cyclometalated complexes with oligonucleotides: insights into redox reactions with DNA.
TL;DR: It is established that the derivatized Ir(III) complexes, with photoactivation, can trigger the oxidation of guanine and the reduction of cytosine, and transient charge occupancy in oligonucleotides when DNA is irradiated in the presence of noncovalently bound complexes.
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DNA mismatch binding and antiproliferative activity of rhodium metalloinsertors.
TL;DR: The correlation between binding affinity and targeting of the MMR-deficient cell line suggests that rhodium metalloinsertors exert their selective biological effects on MMR- deficient cells through mismatch binding in vivo.