J
Jada L. Garzon
Researcher at University of Rhode Island
Publications - 5
Citations - 45
Jada L. Garzon is an academic researcher from University of Rhode Island. The author has contributed to research in topics: Chromatin & Biology. The author has an hindex of 2, co-authored 2 publications receiving 8 citations.
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Journal ArticleDOI
Walking a tightrope: The complex balancing act of R-loops in genome stability.
TL;DR: In this article , the authors discuss the cellular contexts in which R-loops contribute to genomic instability, particularly during DNA replication and double-strand break (DSB) repair.
Journal ArticleDOI
FANCD2 Binding to H4K20me2 via a Methyl-Binding Domain Is Essential for Efficient DNA Cross-Link Repair.
Karissa L. Paquin,Nicholas E. Mamrak,Jada L. Garzon,Juan A. Cantres-Velez,Paul A. Azzinaro,Elizabeth A Vuono,Kevin E. Lima,Jodi L. Camberg,Niall G. Howlett +8 more
TL;DR: This study functionally describes the first FA protein chromatin reader domain and establishes an important link between this human genetic disease and chromatin plasticity.
Journal ArticleDOI
Modulation of the Fanconi anemia pathway via chemically induced changes in chromatin structure.
David A. Vierra,Jada L. Garzon,Meghan A. Rego,Morganne M. Adroved,Maurizio Mauro,Niall G. Howlett +5 more
TL;DR: It is established that chromatin state is a major determinant of the activation of the FA pathway and an important role for the PRC2/EZH2 complex in the regulation of this critical tumor suppressor pathway is suggested.
Posted ContentDOI
Hypoxic response is driven by the BAF form of SWI/SNF
K. Tran,Tomali Chakravarty,Jada L. Garzon,Anita Saraf,Laurence Florens,Michael P. Washburn,Arnob Dutta +6 more
TL;DR: In this article , the authors found that hypoxia regulates levels of unique subunits that define each SWI/SNF complex and that these subunits can be dynamically altered as a response to environmental changes.
Posted ContentDOI
PBRM1 is a vulnerability in ARID1A deficient multicellular tumor spheroids
Tomali Chakravarty,K. Tran,Dinesh Dhamecha,Tyrus Perdue,Jada L. Garzon,Jyothi U. Menon,Arnob Dutta +6 more
TL;DR: In the absence of ARID1A in a MTS model, ARIDs1B continues to be a vulnerability but PBRM1 is identified as a new vulnerability within SWI/SNF, which provides a new target for therapeutic strategies.