Showing papers by "Jae Sik Yu published in 2016"
TL;DR: Systemic investigation of the chemical constituents of M. alba fruits led to the identification of a novel oxolane derivative, namely, odisolane, which might be beneficial in antiangiogenesis therapy for cancer treatment.
Abstract: Mulberry, the fruit of Morus alba L., is known as an edible fruit and commonly used in Chinese medicines as a warming agent and as a sedative, tonic, laxative, odontalgic, expectorant, anthelmintic, and emetic. Systemic investigation of the chemical constituents of M. alba fruits led to the identification of a novel oxolane derivative, (R*)-2-((2S*,3R*)-tetrahydro-2-hydroxy-2-methylfuran-3-yl)propanoic acid (1), namely, odisolane, along with five known heterocyclic compounds (2-6). The structure of the new compound was elucidated on the basis of HR-MS, 1D and 2D NMR ((1)H-(1)H COSY, HSQC, HMBC, and NOESY) data analysis. Compound 1 has a novel skeleton that consists of 8 carbon units with an oxolane ring, which until now has never been identified in natural products. The isolated compounds were subjected to several activity tests to verify their biological function. Among them, compounds 1, 3, and 5 significantly inhibited cord formation in HUVECs. The action mechanism of compound 3, which had the strongest antiangiogenic activity, was mediated by decreasing VEGF, p-Akt, and p-ERK protein expression. These results suggest that compounds isolated from M. alba fruits might be beneficial in antiangiogenesis therapy for cancer treatment.
30 citations
TL;DR: All isolates were evaluated for their antiproliferative activities against four human tumor cell lines and the anti-neuroinflammatory activities of the isolates (1–6) in the lipopolysaccharide-stimulated murine microglia BV-2 cell line by measuring nitric oxide (NO) levels.
Abstract: A new rearranged eudesmane sesquiterpene, named eudeglaucone (1), and five known sesquiterpenes including (+)-faurinone (2) and four eudesmane-type sesquiterpenes (3–6), were isolated from the twigs of Lindera glauca (Sieb. et Zucc.) Blume. The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR (1H-1H COSY, HMQC, HMBC, and NOESY) and HR-MS. Compound 1 was a relatively rare rearranged eudesmane sesquiterpene in terpenoids. All isolates were evaluated for their antiproliferative activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15). Compounds 3 and 6 showed significant cytotoxicity against SK-MEL-2 and HCT-15 cell lines with IC50 values ranging from 9.98 to 12.20 μM. We also investigated the anti-neuroinflammatory activities of the isolates (1–6) in the lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cell line by measuring nitric oxide (NO) levels. All isolates significantly inhibited NO production with IC50 values of 3.67–26.48 μM without inducing cell toxicity.
26 citations
TL;DR: Results show that blocking the MAPKs signaling cascade plays a critical role in mediating the renoprotective effect of Momordicae Semen extract and compounds 1 and 2.
13 citations
TL;DR: In this article, a new phenylpropanoid with a rare natural acetonide group, asarotonide, together with three known phenyl-propanoids were isolated from the rhizomes of Acorus gramineus.
10 citations
TL;DR: In this article, a new phenylpropanoid with a rare natural acetonide group, asarotonide, together with three known phenyl-propanoids were isolated from the rhizomes of Acorus gramineus.
Abstract: A new phenylpropanoid with a rare natural acetonide group, asarotonide, together with three known phenylpropanoids were isolated from the rhizomes of Acorus gramineus. The structure of the new compound was established by extensive spectroscopic data and HR-MS. The antiproliferative activities of the compounds were tested against human cancer cell lines; in addition, inhibitory activities on nitric oxide production were evaluated in an activated murine microglial cell line.