S
Seoung Rak Lee
Researcher at Sungkyunkwan University
Publications - 56
Citations - 930
Seoung Rak Lee is an academic researcher from Sungkyunkwan University. The author has contributed to research in topics: Cornus walteri & Adipogenesis. The author has an hindex of 16, co-authored 54 publications receiving 625 citations.
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Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells.
TL;DR: Experimental evidence is provided that the sclerotia of P. cocos are a potential source of natural anti-inflammatory agents for use in pharmaceuticals and functional foods and the most active compound 1, seco-lanostane triterpenoid, could be a promising lead compound for the development of novel anti- inflammatory agents.
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Sulforaphene suppresses growth of colon cancer-derived tumors via induction of glutathione depletion and microtubule depolymerization.
Sanguine Byun,Sanguine Byun,Seung-Ho Shin,Jiman Park,Semi Lim,Eun-Jung Lee,Chaeyoon Lee,Dong-Eun Sung,Lee Farrand,Seoung Rak Lee,Ki-Hyun Kim,Zigang Dong,Sam W. Lee,Ki Won Lee +13 more
TL;DR: It was determined that sulforaphene is a potent inhibitor of microtubule polymerization while generating reactive oxygen species via the depletion of glutathione and may contribute to the anti-tumor effects of cruciferous vegetables that contain sul foraphene and other isothiocyanates.
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Suppression of 6-Hydroxydopamine-Induced Oxidative Stress by Hyperoside Via Activation of Nrf2/HO-1 Signaling in Dopaminergic Neurons
Seung-Hwan Kwon,Seoung Rak Lee,Yong Joo Park,Moonjin Ra,Yongjun Lee,Changhyun Pang,Ki-Hyun Kim +6 more
TL;DR: Hyperoside, via the induction of Nrf2-dependent HO-1 activation, suppresses neuronal death caused by 6-OHDA-induced oxidative stress, and represents a potential preventive and therapeutic target in Parkinson′s disease management.
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Antioxidant and α-glucosidase inhibitory activities of constituents from Euonymus alatus twigs
TL;DR: In this paper, the chemical constituents of Euonymus alatus (Thunb.) Sieb. (Celastraceae) were investigated and their antioxidant and α-glucosidase inhibitory activities thoroughly studied.
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Anti-adipogenic Pregnane Steroid from a Hydractinia-associated Fungus, Cladosporium sphaerospermum SW67
Seoung Rak Lee,Heesun Kang,Min Jeong Yoo,Sang Ah Yi,Christine Beemelmanns,Jae Cheol Lee,Ki-Hyun Kim +6 more
TL;DR: Findings provide experimental evidence that the steroid derived from Hydractinia-associated C. sphaerospermum SW67 is a potential therapeutic agent for obesity.