Jaehwi Lee

TL;DR: It is suggested that the fairly low oral bioavailability of β-lapachone may be resulted from the first-pass metabolic degradation of α- Lapachone in the liver, small and large intestinal tracts and its low aqueous solubility.

TL;DR: PEG rate of about 90-150% is suggested for matrix tablet formulations, and the exact ratio could be formulated according to the resulting tablet's properties.

TL;DR: Results suggest that ACP-induced nanocurrents alter signal transduction pathways that are involved in the inflammatory response and could therefore be utilized in the treatment of various inflammatory diseases such as arthritis and colitis.

TL;DR: Novel modulatory effects of ceramides on the functional activation of beta1 integrins (CD29) and their associated molecules are reported, using U937 cell-cell or cell-fibronectin (FN) adhesion events, to suggest a novel possibility that ceramide can be used as a therapeutic drug regarding CD29-mediated pathological events.

TL;DR: The data suggest that cafestol may be a novel ERK inhibitor with AP-1-targeted inhibitory activity against PGE(2) production in LPS-activated RAW264.7 cells.