抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Quantum networks provide opportunities and challenges across a range of intellectual and technical frontiers, including quantum computation, communication and metrology. The realization of quantum networks composed of many nodes and channels requires new scientific capabilities for generating and characterizing quantum coherence and entanglement. Fundamental to this endeavour are quantum interconnects, which convert quantum states from one physical system to those of another in a reversible manner. Such quantum connectivity in networks can be achieved by the optical interactions of single photons and atoms, allowing the distribution of entanglement across the network and the teleportation of quantum states between nodes.

The quantum internet

We review the field of cavity optomechanics, which explores the interaction between electromagnetic radiation and nano- or micromechanical motion This review covers the basics of optical cavities and mechanical resonators, their mutual optomechanical interaction mediated by the radiation pressure force, the large variety of experimental systems which exhibit this interaction, optical measurements of mechanical motion, dynamical backaction amplification and cooling, nonlinear dynamics, multimode optomechanics, and proposals for future cavity quantum optomechanics experiments In addition, we describe the perspectives for fundamental quantum physics and for possible applications of optomechanical devices

Cavity Optomechanics

Bose-Einstein condensation (BEC) has been observed in a dilute gas of sodium atoms. A Bose-Einstein condensate consists of a macroscopic population of the ground state of the system, and is a coherent state of matter. In an ideal gas, this phase transition is purely quantum-statistical. The study of BEC in weakly interacting systems which can be controlled and observed with precision holds the promise of revealing new macroscopic quantum phenomena that can be understood from first principles.

Bose-Einstein condensation in a gas of sodium atoms

Ever since its discovery, the Berry phase has permeated through all branches of physics. Over the last three decades, it was gradually realized that the Berry phase of the electronic wave function can have a profound effect on material properties and is responsible for a spectrum of phenomena, such as ferroelectricity, orbital magnetism, various (quantum/anomalous/spin) Hall effects, and quantum charge pumping. This progress is summarized in a pedagogical manner in this review. We start with a brief summary of necessary background, followed by a detailed discussion of the Berry phase effect in a variety of solid state applications. A common thread of the review is the semiclassical formulation of electron dynamics, which is a versatile tool in the study of electron dynamics in the presence of electromagnetic fields and more general perturbations. Finally, we demonstrate a re-quantization method that converts a semiclassical theory to an effective quantum theory. It is clear that the Berry phase should be added as a basic ingredient to our understanding of basic material properties.

/pdf/berry-phase-effects-on-electronic-properties-53dkbbi2er.pdf

Berry phase effects on electronic properties

Ultracold cesium atoms are prepared in the ground energy band of the potential induced by an optical standing wave. We observe Bloch oscillations of the atoms driven by a constant inertial force. We measure the momentum distribution of Bloch states and effective masses different from the mass of the free atom. {copyright} {ital 1996 The American Physical Society.}

Bloch oscillations of atoms in an optical potential.

An optical cavity enhances the interaction between atoms and light, and the rate of coherent atom-photon coupling can be made larger than all decoherence rates of the system. For single atoms, this 'strong coupling regime' of cavity quantum electrodynamics has been the subject of many experimental advances. Efforts have been made to control the coupling rate by trapping the atom and cooling it towards the motional ground state; the latter has been achieved in one dimension so far. For systems of many atoms, the three-dimensional ground state of motion is routinely achieved in atomic Bose-Einstein condensates (BECs). Although experiments combining BECs and optical cavities have been reported recently, coupling BECs to cavities that are in the strong-coupling regime for single atoms has remained an elusive goal. Here we report such an experiment, made possible by combining a fibre-based cavity with atom-chip technology. This enables single-atom cavity quantum electrodynamics experiments with a simplified set-up and realizes the situation of many atoms in a cavity, each of which is identically and strongly coupled to the cavity mode. Moreover, the BEC can be positioned deterministically anywhere within the cavity and localized entirely within a single antinode of the standing-wave cavity field; we demonstrate that this gives rise to a controlled, tunable coupling rate. We study the heating rate caused by a cavity transmission measurement as a function of the coupling rate and find no measurable heating for strongly coupled BECs. The spectrum of the coupled atoms-cavity system, which we map out over a wide range of atom numbers and cavity-atom detunings, shows vacuum Rabi splittings exceeding 20 gigahertz, as well as an unpredicted additional splitting, which we attribute to the atomic hyperfine structure. We anticipate that the system will be suitable as a light-matter quantum interface for quantum information.

/pdf/strong-atom-field-coupling-for-bose-einstein-condensates-in-466j6h6l7h.pdf

Strong atom-field coupling for Bose-Einstein condensates in an optical cavity on a chip.

Although Bose-Einstein condensates of ultracold atoms have been experimentally realizable for several years, their formation and manipulation still impose considerable technical challenges. An all-optical technique that enables faster production of Bose-Einstein condensates was recently reported. Here we demonstrate that the formation of a condensate can be greatly simplified using a microscopic magnetic trap on a chip. We achieve Bose-Einstein condensation inside the single vapour cell of a magneto-optical trap in as little as 700 ms-more than a factor of ten faster than typical experiments, and a factor of three faster than the all-optical technique. A coherent matter wave is emitted normal to the chip surface when the trapped atoms are released into free fall; alternatively, we couple the condensate into an 'atomic conveyor belt', which is used to transport the condensed cloud non-destructively over a macroscopic distance parallel to the chip surface. The possibility of manipulating laser-like coherent matter waves with such an integrated atom-optical system holds promise for applications in interferometry, holography, microscopy, atom lithography and quantum information processing.

Bose–Einstein condensation on a microelectronic chip

We have realized a fiber-based Fabry-Perot cavity with CO2 laser-machined mirrors. It combines very small size, high finesse F>=130000, small waist and mode volume, and good mode matching between the fiber and cavity modes. This combination of features is a major advance for cavity quantum electrodynamics (CQED), as shown in recent CQED experiments with Bose-Einstein condensates enabled by this cavity [Y. Colombe et al., Nature 450, 272 (2007)]. It should also be suitable for a wide range of other applications, including coupling to solid-state emitters, gas detection at the single-particle level, fiber-coupled single-photon sources and high-resolution optical filters with large stopband.

/pdf/fiber-fabry-perot-cavity-with-high-finesse-1avf4ofv46.pdf

Fiber Fabry-Perot cavity with high finesse

We describe manipulation of neutral atoms using the magnetic field of microfabricated current-carrying conductors. It is shown how this method can be used to achieve adiabatic magnetic transport from one reservoir to another. In the first experimental realization of a microfabricated magnetic neutral-atom trap, efficient loading is achieved with a novel mirror-magneto-optic trap. A cloud of rubidium atoms is stored and compressed using the magnetic field of a ``U''-shaped wire carrying a current of 2 A. An evaporation mechanism is demonstrated which removes hot atoms from the trap by collisions with the substrate surface.

/pdf/atomic-micromanipulation-with-magnetic-surface-traps-3ya83eck9t.pdf

Jakob Reichel

Papers

Bloch oscillations of atoms in an optical potential.

Strong atom-field coupling for Bose-Einstein condensates in an optical cavity on a chip.

Bose–Einstein condensation on a microelectronic chip

Fiber Fabry-Perot cavity with high finesse

Atomic Micromanipulation with Magnetic Surface Traps