James A. Huntington

TL;DR: It is concluded that neither arginine 132 nor lysine 133 plays an important role in the binding of heparin pentasaccharide or in the mechanism of heParin activation, suggesting that D-helix extension through charge neutralization is not the mechanism for transmission of conformational change from the heparIn binding site to the reactive center region.

TL;DR: The high occurrence of this mutation and its possible propagation from a few founders suggests an evolutionary advantage, perhaps in decreasing postpartum bleeding.

TL;DR: Soluble recombinant β3 peptides can be used for detection of clinical HPA‐1a antibodies, and testing of FMAIT samples indicated that ΔβA‐Leu33 is the superior peptide for HPA-1a antibody detection, with 96% sensitivity and 95% specificity.

TL;DR: The results indicate that the peptide corresponding to the C-terminal portion of GpIbα and the entire extracellular domain bind exclusively to thrombin's exosite II, which serves to recruitThrombin activity to the platelet surface while leaving exosite I free for PAR-1 recognition.

TL;DR: Several novel SERPINC1 mutations are reported, thereby adding to the knowledge of the molecular background of antithrombin deficiency, and the results point out the importance of future research outside the conventional SERPinc1 gene approach.