James A. Irving

TL;DR: This work aims to provide a systematic literature review and meta-analyses of the determinants of blood clotting disorders and their Kessler’s disease progression as well as some of the mechanisms behind these reactions.

TL;DR: The goals of this work are to provide a carefully curated alignment of serpin sequences, to describe patterns of conservation and divergence, and to derive a phylogenetic tree expressing the relationships among the members of this family.

TL;DR: The distribution and evolution of RCPs that contain homopeptide repeats tracts are considered, and the existence of functional patterns investigated, and it is found that while polyamino acid repeats are extremely rare in prokaryotes, several eukaryote putative homologs of proKaryote RCP-involved in important housekeeping processes-retain the repetitive region, suggesting an ancient origin for certain repeats.

TL;DR: It is proposed that this cytoprotective function, along with similarities in structure are common features of a cohort of intracellular serpin clades from a wide variety of species.

TL;DR: This study characterize 12 serpin-like sequences in the genomes of prokaryotic organisms, extending this protein family to all major branches of life and suggests that all 12 serpins are inhibitory.