Stephen P. Bottomley

TL;DR: Sequence similarity between bacterial and vertebrate MACPF domains suggests that the fold of the CDCs, a family of proteins important for bacterial pathogenesis, is probably used by vertebrates for defense against infection.

TL;DR: DA inhibited the formation of iron‐induced α‐SN amyloidogenic aggregates, suggesting that DA acts as a dominant modulator of α‐ SN aggregation, and support the paradigm emerging for other neurodegenerative diseases that the toxic species is represented by a soluble oligomer and not the insoluble fibril.

TL;DR: The distribution and evolution of RCPs that contain homopeptide repeats tracts are considered, and the existence of functional patterns investigated, and it is found that while polyamino acid repeats are extremely rare in prokaryotes, several eukaryote putative homologs of proKaryote RCP-involved in important housekeeping processes-retain the repetitive region, suggesting an ancient origin for certain repeats.

TL;DR: The novel role for Mal is characterized in facilitating the direct recruitment of TRAF6 to the plasma membrane, which is necessary for TLR2- and TLR4-induced transactivation of NF-κB and regulation of the subsequent pro-inflammatory response.

TL;DR: A new layer of MHC polymorphism is unveiled that affects the generic pathway of Ag loading, revealing an unsuspected evolutionary trade-off in selection for optimal HLA class I loading versus effective pathogen evasion.