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Bradly G. Wouters

Researcher at Princess Margaret Cancer Centre

Publications -  198
Citations -  23452

Bradly G. Wouters is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Unfolded protein response & Hypoxia (medical). The author has an hindex of 61, co-authored 183 publications receiving 20263 citations. Previous affiliations of Bradly G. Wouters include Memorial Sloan Kettering Cancer Center & Maastricht University Medical Centre.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

Franck Pagès, +120 more
- 26 May 2018 - 
TL;DR: The immunoscore provides a reliable estimate of the risk of recurrence in patients with colon cancer and supports the implementation of the consensus Immunoscore as a new component of a TNM-Immune classification of cancer.
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Towards the introduction of the 'Immunoscore' in the classification of malignant tumours.

Jérôme Galon, +56 more
- 01 Jan 2014 - 
TL;DR: In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC or UICCTNM classification.
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Hypoxia signalling through mTOR and the unfolded protein response in cancer

Bradly G. Wouters, +3 more
- 01 Nov 2008 - 
TL;DR: Growing evidence suggests that HIF-, mTOR- and UPR-dependent responses to hypoxia act in an integrated way, influencing each other and common downstream pathways that affect gene expression, metabolism, cell survival, tumorigenesis and tumour growth.
Journal Article

Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

Janice M. Brown, +1 more
- 01 Apr 1999 - 
TL;DR: Because wild-type p53 predisposes cells to a more rapid rate of cell death after DNA damage, that short-term assays have led to the conclusion that mutations in p53 confer resistance to genotoxic agents, this tenet may need to be reexamined for human tumors of nonhematological origin.