J
James A. Shayman
Researcher at University of Michigan
Publications - 175
Citations - 7611
James A. Shayman is an academic researcher from University of Michigan. The author has contributed to research in topics: Ceramide & Fabry disease. The author has an hindex of 50, co-authored 172 publications receiving 7151 citations. Previous affiliations of James A. Shayman include United States Department of Veterans Affairs & Washington University in St. Louis.
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Journal ArticleDOI
Improved inhibitors of glucosylceramide synthase.
TL;DR: A new series of glucosylceramide synthase inhibitors based on substitutions in the phenyl ring of a parent compound, 1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (P4), resulted in the inhibition of glycosphingolipid synthesis in cultured cells at concentrations that did not significantly raise intracellular ceramide levels or inhibit cell growth.
Journal ArticleDOI
Improved inhibitors of glucosylceramide synthase.
Akira Abe,Jin-ichi Inokuchi,Masayuki Jimbo,Hiroshi Shimeno,Atsuo Nagamatsu,James A. Shayman,Girja S. Shukla,Norman S. Radin,Norman S. Radin +8 more
TL;DR: A new series of glucosylceramide synthase inhibitors based on substitutions in the phenyl ring of a parent compound, 1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (P4), resulted in the inhibition of glycosphingolipid synthesis in cultured cells at concentrations that did not significantly raise intracellular ceramide levels or inhibit cell growth.
Journal ArticleDOI
(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an Inhibitor of Ceramidase
Alicja Bielawska,Mathew S. Greenberg,David K. Perry,Supriya Jayadev,James A. Shayman,Charles McKay,Yusuf A. Hannun +6 more
TL;DR: It is demonstrated that D-e-MAPP functions as an inhibitor of alkaline ceramidase in vitro and in cells resulting in elevation in endogenous levels of ceramide with the consequent biologic effects of growth suppression and cell cycle arrest.
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Ganglioside-Linked Terminal Sialic Acid Moieties on Murine Macrophages Function as Attachment Receptors for Murine Noroviruses
Stefan Taube,Jeffrey W. Perry,Kristen Yetming,Sagar P. Patel,Heather Auble,Liming Shu,Hesham F. Nawar,Chang Hoon Lee,Terry D. Connell,James A. Shayman,Christiane E. Wobus +10 more
TL;DR: Data indicate that MNV can use terminal SA on gangliosides as attachment receptors during binding to murine macrophages, suggesting a role for SA during the initial steps of the MNV-1 life cycle.
Journal ArticleDOI
Globotriaosylceramide induces oxidative stress and up-regulates cell adhesion molecule expression in Fabry disease endothelial cells.
Jin Song Shen,Xing Li Meng,Xing Li Meng,David F. Moore,Jane M. Quirk,James A. Shayman,Raphael Schiffmann,Christine R. Kaneski +7 more
TL;DR: This study provided direct evidence that excess intracellular Gb(3) induces oxidative stress and up-regulates the expression of cellular adhesion molecules in vascular endothelial cells.