D
David K. Perry
Researcher at Medical University of South Carolina
Publications - 24
Citations - 2826
David K. Perry is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Ceramide & Apoptosis. The author has an hindex of 19, co-authored 23 publications receiving 2768 citations. Previous affiliations of David K. Perry include Duke University.
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Journal ArticleDOI
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis.
David K. Perry,Mirrian J. Smyth,Mirrian J. Smyth,Henning R. Stennicke,Guy S. Salvesen,Patrick J. Duriez,Guy G. Poirier,Yusuf A. Hannun +7 more
TL;DR: Results identify caspase-3 as a novel target of Zn2+ inhibition in apoptosis and suggest a regulatory role for Zn 2+ in modulating the upstream apoptotic machinery.
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Serine Palmitoyltransferase Regulates de NovoCeramide Generation during Etoposide-induced Apoptosis
David K. Perry,Jill M. Carton,Amit K. Shah,Filmore I. Meredith,David J. Uhlinger,Yusuf A. Hannun +5 more
TL;DR: The results implicate serine palmitoyltransferase as the enzyme controlling de novo ceramide synthesis during apoptosis and begin to define a unique function of ceramide generated from this pathway.
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Ischemic preconditioning protects the mouse liver by inhibition of apoptosis through a caspase-dependent pathway.
TL;DR: Ischemic preconditioning confers dramatic protection against prolonged ischemia via inhibition of apoptosis through down‐regulation of caspase 3 activity, independent of calpain‐like activity or Bcl‐2 expression.
Journal ArticleDOI
(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an Inhibitor of Ceramidase
Alicja Bielawska,Mathew S. Greenberg,David K. Perry,Supriya Jayadev,James A. Shayman,Charles McKay,Yusuf A. Hannun +6 more
TL;DR: It is demonstrated that D-e-MAPP functions as an inhibitor of alkaline ceramidase in vitro and in cells resulting in elevation in endogenous levels of ceramide with the consequent biologic effects of growth suppression and cell cycle arrest.