James Blanchard

TL;DR: Using the monocyte-derived DC (moDC) model, this work sought to describe how PICLC impacts HIV infection within DCs and DC-T cell mixtures and found that in the right combination anti-HIV strategy, PIC LC has the potential to limit HIV infection and boost HIV immunity.

TL;DR: A previously unknown mechanism that may contribute to rapid HIV spread in the gut, a major site of HIV replication after mucosal exposure is described.

TL;DR: Results suggest that rectal HSV-2 infection may increase the susceptibility of macaques to rectal SIVmac239 wild-type (wt) infection even in SIVΔnef-infected animals, and may impact immunological and virological parameters during acute SIV infection.

TL;DR: A macaque study in which psoralen/ultraviolet light-inactivated VV (UV VV) was substituted for replication-competent VV in the multi-envelope DVP protocol is designed to define a practical means of improving VV safety, and encourage advancement of a promising multi- envelopeDVP HIV-1 vaccine candidate.

TL;DR: Direct observation of critically ill rhesus macaques may not yield the most accurate assessment of illness severity, and using video to assess behavior may be helpful for prognosis.