J
James Blanchard
Researcher at Tulane University
Publications - 119
Citations - 5958
James Blanchard is an academic researcher from Tulane University. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 37, co-authored 119 publications receiving 5460 citations.
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Journal ArticleDOI
SHIV Infection Protects Against Heterologous Pathogenic SHIV Challenge in Macaques: A Gold-Standard for HIV-1 Vaccine Development?
Robert E. Sealy,Xiaoyan Zhan,Timothy D. Lockey,Louis N. Martin,James Blanchard,Vicki Traina-Dorge,Julia L. Hurwitz +6 more
TL;DR: Protection from superinfection was statistically significant in test monkeys; this protective state may serve as a 'gold-standard' for HIV-1 vaccine development, as a similar degree of protection against immunodeficiency virus infections in humans would be much desired.
Journal ArticleDOI
A model of genital herpes simplex virus Type 1 infection in Rhesus Macaques.
Meropi Aravantinou,Ines Frank,Géraldine Arrode-Brusés,Moriah L. Szpara,Brooke Grasperge,James Blanchard,Agegnehu Gettie,Nina Derby,Elena Martinelli +8 more
TL;DR: Although HSV‐2 is the major cause of genital lesions, HSV-1 accounts for half of new cases in developed countries and is the most common cause of female genital herpes in developing countries.
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Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques.
Giulia Calenda,Ines Frank,Géraldine Arrode-Brusés,Amarendra Pegu,Keyun Wang,James Arthos,Claudia Cicala,Kenneth A. Rogers,Lisa Shirreff,Brooke Grasperge,James Blanchard,Stephanie Maldonado,Kevin Roberts,Agegnehu Gettie,Francois Villinger,Anthony S. Fauci,John R. Mascola,Elena Martinelli +17 more
TL;DR: The combination of suboptimal amounts of VRC01 and Rh-α4β7 delayed infection, altered antiviral immune responses and minimized CD4+ T cell loss is warranted and may lead to novel preventive and therapeutic strategies.
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Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy.
Edith Jasny,Suzanne Geer,Ines Frank,Panagiotis Vagenas,Meropi Aravantinou,Andres M. Salazar,Jeffrey D. Lifson,Michael Piatak,Agegnehu Gettie,James Blanchard,Melissa Robbiani +10 more
TL;DR: Early initiation of ART prevented virus-induced damage and did not impede mucosal or systemic immune functions in uninfected Chinese rhesus macaques.
Journal ArticleDOI
In vivo binding and retention of CD4-specific DARPin 57.2 in macaques.
Pavel Pugach,Anders Krarup,Agegnehu Gettie,Marcelo J. Kuroda,James Blanchard,Michael Piatak,Jeffrey D. Lifson,Alexandra Trkola,Melissa Robbiani +8 more
TL;DR: It is demonstrated that the CD4-specific DARPin can rapidly and selectively bind its target cells in vivo, warranting further studies on possible clinical use of the DARPin technology.