J
James E. Hixson
Researcher at Texas Biomedical Research Institute
Publications - 62
Citations - 5914
James E. Hixson is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Apolipoprotein B & Genetic linkage. The author has an hindex of 28, co-authored 62 publications receiving 5808 citations. Previous affiliations of James E. Hixson include University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
James E. Hixson,D. T. Vernier +1 more
TL;DR: This work has used restriction isotyping (restriction enzyme isoform genotyping) for rapid typing of common apolipoprotein E isoforms (E2, E3, E4) and distinguished each of the isoforms by a unique combination of HhaI fragment sizes that enabled unambiguous typing of all homozygotic and heterozygotic combinations.
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Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans: The San Antonio Family Heart Study
Braxton D. Mitchell,Candace M. Kammerer,John Blangero,Michael C. Mahaney,David L. Rainwater,Bennett Dyke,James E. Hixson,Richard D. Henkel,R. Mark Sharp,Anthony G. Comuzzie,John L. VandeBerg,Michael P. Stern,Jean W. MacCluer +12 more
TL;DR: Among Mexican Americans from San Antonio (Tex), the relative contributions of both genetic and environmental influences to a large panel of cardiovascular risk factors, including serum levels of lipids, lipoproteins, glucose, hormones, adiposity, and blood pressure are quantified.
Journal ArticleDOI
Apolipoprotein E polymorphisms affect atherosclerosis in young males. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group.
TL;DR: Investigators in eight communities collected aortas, right coronary arteries, blood and liver samples, and associated information from 720 young males, aged 15-34 years, who died of external causes, suggesting that genotypic effects on arterial lesions may not be mediated entirely by changes in serum cholesterol concentrations.
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Normal Variation in Leptin Levels Is Associated with Polymorphisms in the Proopiomelanocortin Gene, POMC*
James E. Hixson,Laura Almasy,Shelley A. Cole,Shifra Birnbaum,Braxton D. Mitchell,Michael C. Mahaney,Michael P. Stern,Jean W. MacCluer,John Blangero,Anthony G. Comuzzie +9 more
TL;DR: It is concluded that variation in POMC is associated with normal variation in serum leptin levels, providing further evidence that PomC may be the leptin QTL previously identified in Mexican American families.
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A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans.
Braxton D. Mitchell,John Blangero,Anthony G. Comuzzie,Laura Almasy,Alan R. Shuldiner,Kristi Silver,Michael P. Stern,Jean W. MacCluer,James E. Hixson +8 more
TL;DR: It is concluded that the Trp64Arg variant is associated with obesity in this Mexican American population by allowing us to account for variation attributable to another obesity susceptibility locus and to background genes.